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Research Article Open access CC BY 4.0

Plasma Cyclophilin A as a Novel Biomarker in Chronic Nephropathy

Mohy Eldin Abd EL-Fattah, Taghrid B. El-abaseri, Hegazy Mohamed Abd Elaziz Mohamed

International Journal of Biochemistry Research & Review · pp. 63–72 · Published 31 Dec 2020

10.9734/ijbcrr/2020/v29i1030238

Abstract

Background: Type 2 diabetes mellitus (DM) is the most common cause of end- stage renal disease. Albuminuria is the foremost commonly utilized marker to anticipate onset of diabetic nephropathy (DN) without sufficient affectability and specificity to identify early DN. Aim: This study aimed to evaluate Plasma cyclophilin A (CypA) as a new biomarker for early DN. Methods: This cross sectional study included 125 Egyptian subjects attending the out Patients Clinic of the Department of Internal Medicine, 10Th of Ramadan city Health Insurance Hospital and divided into-:control group, patient with diabetic mellitus, patients with Diabetic nephropathy and patient with diabetic nephropathy and other complications. Patients were subjected to measurement of plasma cyclophyline A, FBS, HbAIC, serum creatinine, serum urea, serum uric acid, k, Na, serum phosphorus, Albumin:Creatinine Ratio, GFR, Chol, TG, LDL HDL, AST, ALT, T.BIL, D.BIL ALB, TP, GLB and A/G ratio. Results: Results showed that Cyclophilin A was significantly correlated with duration of DM, CR, Urea, UR.A, Na, phosphorus, ACR, Chol, TG, LDL, AST, ALT, T.BIL, D.BIL. Meanwhile, Cyclophilin A was negatively correlated with HA1C, K, GFR, HDL, ALB, TP, GLB and A/G ratio. At cut-off level ≥84.14, cyclophilin A had 91% sensitivity and 62% specificity for diagnosing diabetic nephropathy. Conclusion: CypA can be used as an early marker for DN as we found early significant high levels of urinary CypA in diabetic patients with stage 2 DN even before the appearance of albuminuria.

Plasma cyclophilin A DN

References (6)

  1. 1 Renal Insufficiency in the Absence of Albuminuria and Retinopathy Among Adults With Type 2 Diabetes Mellitus [DOI]
  2. 2 Markers of and Risk Factors for the Development and Progression of Diabetic Kidney Disease [DOI]
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Cited by 4

Urinary cyclophilin A as an early marker of chronic kidney disease with underlying type 2 diabetes

Patutong Chatchawal, Patcharaporn Tippayawat, Thidarat Somdee · Scientific Reports · 2024

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