Skip to content
Research Article Open access CC BY 4.0

Phytochemical Screening and Anti-diarrheal Activity of the Pulp and Seed Extracts of Ziziphus mauritiana in Rats

Martha Asugu Mbahi, Mary Asugu Mbahi, Pigweh Isa Amos

International Journal of Biochemistry Research & Review · pp. 1–9 · Published 21 Dec 2018

10.9734/IJBCRR/2018/45674

Abstract

In the present study, attempt was made to evaluate the phytochemical composition and anti-diarrheal activity of the seed and pulp extract of Ziziphus mauritania. The anti-diarrheal activity of the crude seed and pulp were evaluated using castor oil induced diarrheal model, charcoal meal test and anti-fluid accumulation test in rats. The result of phytochemical test indicated that tannins, flavonoids, saponin, cyanogenic glycosides, and terpenoids were present in both seed and pulp. In the castor oil induced model both the seed and pulp extract significantly prolonged diarrheal onset was observed in treated rats compared to the negative control. Similarly, in the fluid accumulation test, the extract of the seed and pulp produced a significant decline in volume of intestinal contents. Results from the charcoal meal test revealed that all the extract produced a significant anti-motility effect. Based on the findings of this work, the pulp extract of this plant possess anti-diarrheal properties and validates its use in traditional medicine for the treatment of diarrhea.

Ziziphus mauritania diarrheal charcoal meal castor oil

References (16)

  1. 1 Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria [DOI]
  2. 2 Developing the medicinal plants sector in northern India: challenges and opportunities [DOI]
  3. 3 Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis [DOI]
  4. 4 Enteropooling assay: A test for diarrhea produced by prostaglandins [DOI]
  5. 5 Contribution to the ethnobotanical, phytochemical and pharmacological studies of traditionally used medicinal plants in the treatment of dysentery and diarrhoea in Lomela area, Democratic Republic of Congo (DRC) [DOI]
  6. 6 Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP 3 receptors [DOI]
  7. 7 Inhibitors of nitric oxide synthetase prevent castor‐oil‐induced diarrhoea in the rat [DOI]
  8. 8 Investigations on the Gastroprotective and Antidiarrhoeal Properties of Ternatin, a Tetramethoxyflavone fromEgletes viscosa [DOI]
  9. 9 Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara [DOI]
  10. 10 Novel targets for the control of secretory diarrhoea [DOI]
  11. 11 Antidiarrhoeal activity of Ziziphus mauritiana root extract in rodents [DOI]
  12. 12 Antibacterial, antidiarrhoeal, and cytotoxic activities of methanol extract and its fractions of Caesalpinia bonducella (L.) Roxb leaves [DOI]
  13. 13 The Medicinally Important Leafy Vegetables of Southwestern Nigeria
  14. 14 Immune system control of rat and rabbit colonic electrolyte transport. Role of prostaglandins and enteric nervous system. [DOI]
  15. 15 The needs of the people [DOI]
  16. 16 Antidiarrhoeal activity of rind of Punica granatum [DOI]

Cited by 8

Characterization of pharmacological properties of methanolic seed and stem bark extracts of Ziziphus mauritiana (BAU Kul) using in-vitro and in-vivo animal (Swiss albino male mice) model

Md. Khokon Miah Akanda, A. H. M. Nazmul Hasan · Clinical Phytoscience · 2021

Medicinal and Nutritional Importance of Ziziphus mauritiana in Human Health

Md. Khokon Miah Akanda, Sanzia Mehjabin, Nazia Hoque · Medicinal Plants and their Bioactive Compounds in Human Health: Volume 2 · 2026

Phytochemical constituents and antibacterial activities of 45 Malay traditional medicinal plants

Ibrahim Abuga, Shaida Fariza Sulaiman, Ridhwan Abdul Wahab · Journal of Herbal Medicine · 2022

Showing 3 of 8 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

32

Page views

0

PDF downloads

1

Outbound clicks

8

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.