Effect of H. Pylori on Fibrinogen Level among Sudanese Patients at Khsartoum State

Abstract

Background: Helicobacter pylori (H. pylori) is a gram-negative, spiral shaped pathogenic bacterium that specifically colonizes the gastric epithelium causing chronic gastritis, peptic ulcer disease, and/or gastric malignancy. Aim: To assess the effect of H. pylori on fibrinogen level of Sudanese patients with diabetes millets (D.M) living in Khartoum state. Subjects and Methods: This was case control study conducted among Sudanese diabetic patients during the period from May 2018 to July 2021. A total of 181 diabetics patients are involved in this study. Citrated blood and stool samples were collected from each participant. All stool samples were tested for the presence of H. pylori antigen by using commercially available H. pylori antigen detection card. Based on the result examination for H. pylori the study population are sub grouped in two groups one group 124 of cases with Positive H. pylori antigen and another group 57 of     controls with negative H. pylori infection. Both groups were assessed for the fibrinogen level. Data was gathered and analyzed by using SPSS version 20. Results: Our results revealed that cases have slightly higher values of fibrinogen levels 326.29± 89.99 mg/dl compared to 309.47± 90.82 mg/dl for control group. However, the statistical analysis indicate that the difference was remain insignificant with P-value of 0.246. Among cases group gender concerned the fibrinogen concentration mean in the plasma of male 336.2±98.5 mg/dl was higher than female  311.1±73.4 mg/dl. Conclusion: they were insignificant association between fibrinogen level and presence of H. pylori infection among Sudanese diabetic patients. gender concerned the fibrinogen concentration in the plasma in H. pylori among males showed higher levels than females.