Overlap Syndrome: Systemic Lupus Erythematosus and ANCA  Vasculitis in a Case Report

Hanane Benjelloun; Asmaa Rattal; Afaf Amir; Hanaa Harraz; Nahid Zaghba; Khadija Chaanoun; Najiba Yassine

doi:10.9734/jammr/2024/v36i55442

Research Article Open access CC BY 4.0

Overlap Syndrome: Systemic Lupus Erythematosus and ANCA Vasculitis in a Case Report

Hanane Benjelloun, Asmaa Rattal, Afaf Amir, Hanaa Harraz, Nahid Zaghba, Khadija Chaanoun, Najiba Yassine

Journal of Advances in Medicine and Medical Research · pp. 337–342 · Published 10 May 2024

10.9734/jammr/2024/v36i55442

Abstract

Introduction: Microscopic polyangiitis is a systemic necrotising vasculitis that predominantly affects small-calibre vessels. It may be associated with systemic lupus erythematosus (SLE) as part of an overlap syndrome, but there are very few reports of this in the literature. Case Report: We report the case of a 19-year-old patient admitted with moderate haemoptysis, epistaxis and petechial purpura revealing intra-alveolar haemorrhage with a strongly positive P-ANCA. In addition, blood tests for antinuclear antibodies and rheumatoid factor were positive, with renal involvement suggesting associated lupus as part of an overlap syndrome. Progression was good with corticoide and immunosuppressant treatment. Conclusion: The clinical presentation of overlap syndrome is rare and severe, with a dual immunological profile of antinuclear antibodies and neutrophil cytoplasm.

Overlap treatment Lupus corticoids haemorrhage

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Hanane Benjelloun, Asmaa Rattal, Afaf Amir, Hanaa Harraz, Nahid Zaghba, Khadija Chaanoun, Najiba Yassine (2024). Overlap Syndrome: Systemic Lupus Erythematosus and ANCA Vasculitis in a Case Report. Journal of Advances in Medicine and Medical Research , 337–342. https://doi.org/10.9734/jammr/2024/v36i55442

Affiliations

Hanane Benjelloun — Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Asmaa Rattal — Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Afaf Amir — Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Hanaa Harraz — Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Nahid Zaghba — Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Khadija Chaanoun — Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.
Najiba Yassine — Department of Pulmonology, CHU Ibn Rochd Casablanca, Morocco.

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