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Research Article Open access CC BY 4.0

TREAT-B has Good Accuracy in Selecting HBV Infected Patients for Treatment in Sudan

Mogahid Mahmoud Elhasan, Omer Osman Kheir, Yashwi Haresh Patwa, Aya Tarig Bakhit, Hala Ibrahim Abdalla

Asian Journal of Medicine and Health · pp. 204–211 · Published 28 Dec 2022

10.9734/ajmah/2022/v20i12784

Abstract

Non-invasive and invasive diagnostic methods, which are not readily available in Sudan, are used to guide HBV treatment. Africa adopted the TREAT-B as a straightforward score in 2018 to identify patients in need of anti-HBV treatment. Objective: To compare the diagnostic accuracy of the TREAT-B score to the standard scores EASL and AASLD in HBV patients. Methods: At Ibn Sina Specialized Hospital, 108 HBV patients were enrolled in an analytical cross-sectional study (January- October 2019). Data was collected using an interviewer-administered questionnaire and analyzed using SPSS. Results: Eight patients (7.4%) were eligible for therapy under the AASLD recommendations, 18 patients (16.7%) were suitable under the EASL guidelines, and twenty-seven patients (25%) were eligible under the TREAT-B guidelines. According to the Wald statistic, the AUROC of TREAT-B (0.883; 95% CI 0.790-0.976; Sen. 85.3%; Sp. 70.3%) was substantially higher than the AUROC of the AASLD criteria (0.722; 95% CI 0. 0.566-0.878; Sen. 74.4%; Sp. 69.8%); and lower than the AUROC of the EASL criteria (0.952; 95% CI 0.790-0.976. Conclusion: The TREAT-B score was effective at identifying HBV-infected patients who should receive antiviral treatment.

Hepatitis B treatment sensitivity and specificity diagnostic antiviral therapy

References (25)

  1. 1 EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection [DOI]
  2. 2 Chronic hepatitis B: Update 2009 # [DOI]
  3. 3 The American Journal of Tropical Medicine and Hygiene [DOI]
  4. 4 Transactions of the Royal Society of Tropical Medicine and Hygiene [DOI]
  5. 5 The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013 [DOI]
  6. 6 Acceptability and feasibility of a screen-and-treat programme for hepatitis B virus infection in The Gambia: the Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) study [DOI]
  7. 7 Reducing the neglected burden of viral hepatitis in Africa: Strategies for a global approach [DOI]
  8. 8 Development of a simple score based on HBeAg and ALT for selecting patients for HBV treatment in Africa [DOI]
  9. 9 Seroepidemiology of hepatitis B virus in Addis Ababa, Ethiopia: transmission patterns and vaccine control [DOI]
  10. 10 Epidemiology of viral hepatitis in Sudan [DOI]
  11. 11 Molecular characterization of hepatitis B virus in liver disease patients and asymptomatic carriers of the virus in Sudan [DOI]
  12. 12 Characteristics and Management of Patients with Chronic Hepatitis B in an Integrated Care Setting [DOI]
  13. 13 Prevalence of chronic hepatitis B virus infection and infrastructure for its diagnosis in Madagascar: implication for the WHO’s elimination strategy [DOI]
  14. 14 Hepatitis B and C in Juba, southern Sudan: results of a serosurvey [DOI]
  15. 15 Prevalence of hepatitis B virus infection in the Gezira State of Central Sudan [DOI]
  16. 16 Epidemiology of Hepatitis B in the Gezira Region of Sudan [DOI]
  17. 17 Prevalence of chronic kidney disease in patients with chronic hepatitis B: A cross‐sectional survey [DOI]
  18. 18 Performance of two simplified HBV treatment criteria (TREAT-B score and WHO guidelines) in Burkina Faso, West Africa [DOI]
  19. 19 HIV, HBV, delta-agent and Treponema pallidum infections in two rural African areas [DOI]
  20. 20 A novel score to select patients for treatment in chronic hepatitis B: Results from a large Ethiopian cohort [DOI]
  21. 21 Clinical utility of TREAT-B score in African and non-African HBV-infected patients living in Europe [DOI]
  22. 22 Seroprevalence and epidemiological factors of hepatitis B virus (HBV) infection in Eastern Sudan [DOI]
  23. 23 Prevalence of Lichen Planus in Hepatitis B Patients Attending Ibn Sina Hospital
  24. 24 International Journal of Medicine and Medical Sciences [DOI]
  25. 25 Clinical and Experimental Gastroenterology [DOI]

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