Endocrine Dysfunctions in Renal Tubular Disorders

Abstract

This is a review article with narratives on a rare discussion of existence of hormonal dysfunctions in variants of renal tubular acidosis (RTA), acquired and congenital renal tubular disorders, with focus on the molecular and physiological defects. The renal tubules primarily function in excretion of hydrogen ions and filtration of bicarbonates, and any form of damage may interfere with this functions and subsequently lead to chronic kidney disease. There are myriads of causes of renal tubular disease with subsequent development of hormonal abnormalities. The aim is to explore existing literatures and knowledge in understanding the hormonal changes associated with various renal tubular disorders, highlighting different renal tubular disorders like Fanconi’s syndrome, Liddle’s disease, Barter’s syndrome, and Gittelman’s syndrome, elucidate the molecular and pathophysiological basis of various renal tubular disorders and associated endocrine disorders. Articles/literatures’ are selected using keywords below and searching various literatures and books on the internets for common renal tubular disorders. This is part of students project aim to teach and improves integration and interactive learning process in Pathophysiology.