Background: Obesity is a chronic condition described as excessive fat accumulation, which has the potential to severely impact one’s health. It develops through a combination of several factors such as genetics, metabolic conditions, diet, physical activity and much more. The rat...
Open access
Research Article10.9734/irjgh/2026/v9i1139
Background: Obesity is a major public health challenge associated with numerous chronic conditions, including diabetes, polycystic ovarian syndrome(PCOS), hypertension, stroke, gastroesophageal reflux disease( GERD), metabolic dysfunction-associated steatotic liver disease (MASLD...
Open access
Research Article10.9734/irjgh/2026/v9i1137
Medullary breast carcinoma (MBC) is a rare histological subtype of invasive breast cancer, accounting for less than 5% of all breast malignancies, and presents with a unique clinical paradox. Despite its aggressive histopathological features such as high-grade nuclei, prominent l...
Open access
Research Article10.9734/jcti/2025/v15i3314
Hypertensive disorders of pregnancy and pregnancy-induced hypertension(PIH) are often erroneously often erroneously used interchangeably and in remote past collectively termed "toxemia of pregnancy". This continues to represent a critical global health concern, contributing signi...
Open access
Research Article10.9734/ijrrgy/2025/v8i1131
Pregnancy-induced hypertension (PIH), also referred to as toxaemia of pregnancy(obsolete) is a spectrum of multi-systemic dysfunction in pregnancy, usually seen in the third trimester in approximately 6–8% of pregnancies in the United States, according to the National High Blood...
Open access
Research Article10.9734/ijrrgy/2025/v8i1129
Objectives: To retrospectively examine the mortality trend in the USA from 1999 to 2018 using a basic statistical model while examining multiple variables. The inferential and descriptive statistical tools will be prioritized to elucidate the mortality of both years in simple ter...
Open access
Research Article10.9734/acri/2024/v24i9876
To report and review a case of prolactin-producing pituitary tumor presenting with mass effects, hormonal deficiency, and neurogenic diabetes insipidus in a nulliparous woman of Afro-Caribbean descent. The patient presented with dull-aching headaches associated with worsening vis...
Open access
Research Article10.9734/air/2023/v24i5957
Adedeji Okikiade, Twanna Browne-Caesar, Olayinka Afolayan-Oloye, Rasheed Agboola & Kevin Browne·Advances in Research·2023
Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), affects small arteries of the skin in patients with end-stage renal failure, dialysis patients, and patients with hypercalcemia. The condition is characterized by the calcification of small blood vessels leading t...
Open access
Research Article10.9734/air/2023/v24i5953
Dermatomyositis is a chronic progressive autoimmune disease of unknown etiology and rare occurrence worldwide. It is an immunologically mediated idiopathic inflammatory disease in which damage to small blood vessels contributes to injury and inflammation of muscle and skin. Derma...
Open access
Research Article10.9734/air/2023/v24i5954
The fibroblast growth factor receptor 3 (FGFR3) gene mutations were identified to be involved in the pathogenesis of most chondropathies. The FGFR3 gene encodes the FGFR3 receptor and is involved in the regulation of bone growth by limiting the ossification of long bones. Mutatio...
Open access
Research Article10.9734/air/2023/v24i5956
Kluver Bucy Syndrome (KBS) was initially reported by Sanger Brown and Edward Albert Sharpey-Schafer. In 1939, a bilateral temporal lobectomy was conducted on a Rhesus monkey named Aurora. Three weeks after this procedure, Aurora began to exhibit behavioral changes. These behavior...
Open access
Research Article10.9734/indj/2022/v18i3350
Adedeji Okikiade, Nourhan Abdulrahman, Miriam Tikanide, Jeffrey Ndu, Annah Akoth, Esther Akinyode, Twanna Browne-Caesar & Aromedonghene Osharode·Asian Journal of Research in Nephrology·2022
Alport syndrome (AS), also known as hereditary nephrosis, is an X-linked genetic disease that predominantly affects type IV collagen mainly in the kidneys and the eyes. It primarily affects males, particularly children, and can be transmitted via autosomal dominant and recessive...
Adedeji Okikiade, Aromedonghene Osharode, Olayinka Oloye-Afolayan, Damisola Ogunesan, Oyewole Adijat, K. Ubah Chibuike & Kevin Browne·Advances in Research·2022
The human body is a complex structure with the innate ability to protect, defend, repair, and heal after damage or disease. For decades, medicine has faced problems that need the evolution of standard treatments and finding a way to accelerate the regenerative capabilities of the...
Open access
Research Article10.9734/air/2022/v23i6920
Menetrier Disease (MD) is a rare acquired disease that affects middle-aged men in their mid 40's and, to a lesser extent, women and children. Pierre Eugene Menetrier first described it. It is a premalignant disorder, sometimes associated with Helicobacter Pylori in adults, and Gi...
Adedeji Okikiade, Edward Taylor, Norhan Abdulrahman, Oyeniyi Imoleayo, Miriam Tikanide, Aromedonghene Osharode & Damisola Ogunesan·International Research Journal of Oncology·2022
Paraneoplastic Neurological Syndromes (PNS) are a rare spectrum of non-metastatic manifestations likely secondary to T-cell or auto-antibodies induced neuronal dysfunction or cell death and are mostly associated with soft tissue cancers. PNS arises from either the cell membrane b...
Adrenoleukodystrophy (ALD) is caused by an X-linked inborn error of metabolic disorder due to the mutation of ATP binding cassette subfamily D member 1 (ABDC 1) gene. Three types of ALD cerebral form affect children aged 5-10, while the adrenomyeloneuropathy (AMN) form affects mi...
Krabbe disease (or Globoid cell leukodystrophy) is a rare mutation of a gene found on chromosome 14q31 responsible for the production of the enzyme called galactocerebrosidase (G ALC), which breaks down two galactolipids; galactosyl-ceramide and galactosylsphingosine (psychosine)...
The gastrointestinal systems (GIT) and endocrine systems are integrated into a well-coordinated complex to meet the metabolic needs of the body. The endocrine functions and possible dysfunctions are less emphasized in the medical curriculum. Hormones are synthesized and released...
Adedeji Okikiade, Aromedonghene Osharode, Adijat Oyewole, Damisola Ogunesan, Dolapo Oladejo, Ibukunoluwa Oshobu & Kevin Browne·Asian Journal of Medicine and Health·2022
Osteoarthritis (OA) is the most seen form of arthritis, affecting a population of about 3.3 to 3.6% worldwide. In the ranking, it is the 11th most incapacitating disease worldwide, and in about a 43million people, it causes mild to severe disability. Estimated that 80% of the po...
Open access
Research Article10.9734/ajmah/2022/v20i1030506
Adedeji Okikiade, Ikeokwu Anderson, Twanna Browne-Caesar, Kevin Brown, Rebecca Lawrence, Daniel E. Osieme & O. Funmilayo Janet·Asian Journal of Immunology·2021
Background: More than 100 human diseases are due at least in part to an inappropriate immune system response that results in damage to an individual’s organs, tissues, or cells. Immunological diseases can affect any part of the body, and have myriad clinical manifestations that c...
Background: Systemic Lupus Erythematous (SLE) is a rare, severe and lasting autoimmune disease that can vary in severity from mild to possibly life-threatening with a multi-system manifestation characterized by symptoms relating to joint, skin or mucosal inflammation, or with a v...
Open access
Research Article10.9734/ajmah/2021/v19i230305
Adedeji Okikiade, Ikeokwu Anderson, Olayinka Afolayan-Oloye, Olanrewaju Adeola O. & Mane Paulpillai·Asian Journal of Immunology·2021
Background: Type 1 Diabetes Mellitus (TID), is a disease that has long been connoted to as insulin-dependent, childhood-onset, young adult-onset or juvenile onset diabetes with essential insulin deficiency that requires daily insulin administration with peak onset during puberty...
Rasheed Agboola, Adedeji Okikiade & Olayinka Afolayan-Oloye·Advances in Research·2023
Breast cancer is a leading cause of cancer related death among women worldwide and it is a complex disease characterized by its heterogeneity. The heterogenous characteristic of the breast cancer is responsible for its aggressiveness and treatment resistance. Breast cancer stem c...
Open access
Research Article10.9734/air/2023/v24i4943
In recent years, stem cell therapy has been considered a novel therapy for human subjects with coronary artery disease and heart failure. While stem cells of different types have been successfully isolated in laboratory settings and transplanted into animal models, doubts still e...
Open access
Research Article10.9734/ca/2022/v11i4294
Nmezi Chidiadi, Oladejo Dolapo, Deborah Matt-Ojo, Nwoke Daniel, Reisha Browne-Caesar & Adedeji Okikiade·Asian Journal of Medicine and Health·2022
Germ cell tumors (GCTs) in the central nervous system (CNS), occurring in the first and second decade of life, mainly affect children and young adults typically. Ages from 10-19 years are the peak incidence. In patients younger than 20 years,3-5% of all or most intracranial tumor...
Open access
Research Article10.9734/ajmah/2022/v20i1030508
Edim Glory, Okundaye Daniel, Udoaka Favour, Adijat Oyewole, Kevin Browne, Adedeji Okikiade & Olayinka Afolayan-Oloye·Asian Journal of Medicine and Health·2022
The pineal gland is a small endocrine gland in the brain that regulates the circadian rhythm in humans. It is responsible for melatonin production, also produced by parenchymal and glial cells. Pineal region tumors account for 3–11% of pediatric brain tumors, and 1% of adult brai...
Open access
Research Article10.9734/ajmah/2022/v20i1030507
This is a review article with narratives on a rare discussion of existence of hormonal dysfunctions in variants of renal tubular acidosis (RTA), acquired and congenital renal tubular disorders, with focus on the molecular and physiological defects. The renal tubules primarily fun...
Introduction: Adolescents in the Caribbean region continue to experience poor reproductive health outcomes, including high rates of first birth before the age of 20 years. Teenage pregnancies are a worldwide cause of concern. According to the World Health Organization (WHO), abou...
Open access
Research Article10.9734/ajpcb/2021/v4i152