New Kid on the Block: A First Look at the Clinical Use of Pitolisant for Narcolepsy
Andrea Cuamatzi Castelan Castelan, Virginia Skiba, Luisa Bazan, Kenneth Moss, Meeta Singh, Christopher Drake, Philip Cheng
International Journal of Medical and Pharmaceutical Case Reports · pp. 1–5 · Published 1 Feb 2021
10.9734/ijmpcr/2021/v14i130120Abstract
Aims: Highlight pitolisant as an effective treatment for narcolepsy. Case Report: We describe two patients treated with pitolisant. Patient A showed decreased daytime sleepiness and improved social functioning. Patient B struggled to find a dose that kept side effects at a minimum. Discussion: This orphan drug has a unique mechanism of action, that combined with dosing flexibility allows for a treatment option that can better attend to individual differences in patient needs. Conclusion: The use of pitolisant presents some benefits and challenges, nonetheless offering a promising treatment for narcolepsy.
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