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Research Article Open access CC BY 4.0

The Effect of Immunotherapy on Some Immunological Parameters of Airway Allergic Patients in Province of Babylon/Iraq

Salwa Ahmed Alkarady, Frial Gemeel Abd

Journal of Applied Life Sciences International · pp. 1–7 · Published 3 Jun 2016

10.9734/JALSI/2016/25592

Abstract

Twenty-fife blood samples had been collected from patients who attend the center of the allergy and asthma in the province of Babylon, 25 samples from patient who have received subcutaneous immunotherapy, 10 samples from non-allergic persons as a control. These samples were categorized into three groups (before treatment group, after treatment group and control group), the level of immune parameters, which includes histamine, IL-10 and IL-12 have been measured by using ELISA technique. The level of histamine for the first group (before treatment) has reached 34.8292±6.47680 ng/ml as compared with the second group (after treatment) which was 9.3238±3.55296 ng/ml and control is 6.9844±3.05477 ng/ml, while the level of IL-10 for the first groupis14.9604±6.48170 pg/ml as compared with second group which was 43.0476±21.26668  pg/ml and control is 24.4969±10.21066 pg/ml, finally the level of IL-12 for the first group was  17.753±8.39343 pg/ml as compared with second group which was 39.1929±17.73975 pg/ml and control  26.7731±12.93092 pg/ml. The group of immunotherapy treated patients was  divided into four subgroups, according to the period of immunotherapy treatment which were two months, six months, twelvemonths and more than twenty-four months, It had been found that there was a gradual decrease in the level of histamine with increasing the period of immunotherapy treatment that are 11.1811±5.33203 ng/ml, 9.8948±2.91382 ng/ml, 8.8024±2.57390 ng/ml and 8.1191±5.76472 ng/ml respectively, on the contrary, for IL-10 its level increased with increasing the period of immunotherapy treatment that were 13.9605±2.36278 pg/ml, 39.5547±16.60696 pg/ml,  56.8740±11.15175 pg/ml and 65.6659±2.80207 pg/ml respectively. The same thing for the level of IL-12 which increased with increasing the period of immunotherapy treatment that were 16.1298±4.70059 pg/ml, 30.5796±5.40110 pg/ml, 54.0523±5.63154 pg/ml and 56.4601±1.24127 respectively.  

Allergic diseases immunotherapy histamine IL-10 IL-12 type 1 regulatory T cells

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