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Research Article Open access CC BY 3.0

Monosodium Glutamate Induces Oxidative Stress and Affects Glucose Metabolism in the Kidney of Rats

Onyema Oscar Okwudiri, Alisi Chinwe Sylvanus, Ihetuge Adaeze Peace

International Journal of Biochemistry Research & Review · pp. 1–11 · Published 24 Mar 2012

10.9734/IJBCRR/2012/827

Abstract

Monosodium glutamate (MSG) is a widely used flavour enhancer with a number of adverse effects. Earlier studies have shown the induction of oxidative stress in some organs of experimental animals after chronic administration of MSG. Some reports have also shown some alterations in hepatic glucose metabolism as a result of MSG administration. In this study, we have tested the hypothesis that alteration in glucose metabolism following MSG administration might be a contributor to the changes in the markers of oxidative stress observed in the animals. Twenty four male Wistar rats were divided into two groups. MSG was orally administered to one group of rats at a dose of 4g/kg body weight for ten days while the other group received normal saline. MSG-treated rats showed a significant alteration (P<0.05) in a number of oxidative stress parameters and a significant (P<0.05) increase in the activity of glucose-6-Phosphatase (G6Pase), corroborating earlier observations. In addition, there was a decrease in the activity of glucose-6-phosphate dehydrogenase (G6PD) and a significantly (P<0.05) higher blood glucose and renal glucose concentration in MSG-treated rats. There was no change in renal glycogen concentration following MSG administration. The pattern of induction of oxidative stress and alteration of glucose metabolic enzymes in the animals is an indication that oxidative stress induced by MSG in the renal tissues of rats might be contributed by increased tissue glucose concentration resulting from enhanced renal gluconeogenesis.

Monosodium glutamate oxidative stress glucose-6-phosphatase glucose-6-phosphate dehydrogenase

References (38)

  1. 1 PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT [DOI]
  2. 2 Glutathione S-Transferases [DOI]
  3. 3 The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase [DOI]
  4. 4 Colorimetric assay of catalase [DOI]
  5. 5 Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite [DOI]
  6. 6 Oxidative stress in neurodegeneration: cause or consequence? [DOI]
  7. 7 Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation’ in diabetes [DOI]
  8. 8 Glucose-6-phosphate Dehydrogenase [DOI]
  9. 9 Hyperglycemic Pseudohypoxia and Diabetic Complications [DOI]
  10. 10 Hyperglycemie and Microvascular and Macrovascular Disease in Diabetes [DOI]
  11. 11 Effects of Calmodulin Antagonists on Radiation-induced Lipid Peroxidation in Microsomes [DOI]
  12. 12 Free radical generation by early glycation products: A mechanism for accelerated atherogenesis in diabetes [DOI]
  13. 13 Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: modulatory role of vitamin C, vitamin E and quercetin [DOI]
  14. 14 Effects of Antioxidants in Diabetes-Induced Oxidative Stress in the Glomeruli of Diabetic Rats [DOI]
  15. 15 Effects of myricetin on glycemia and glycogen metabolism in diabetic rats [DOI]
  16. 16 Effect of vitamin E on monosodium glutamate induced hepatotoxicity and oxidative stress in rats.
  17. 17 Chemoprotective effect of lipoic acid against cyclophosphamide-induced changes in the rat sperm [DOI]
  18. 18 Monosodium L-Glutamate: Its Pharmacology and Role in the Chinese Restaurant Syndrome [DOI]
  19. 19 Predictors of 10-year macrovascular and overall mortality in patients with NIDDM: the Munich General Practitioner Project [DOI]
  20. 20 Toxicity of hypercaloric diet and monosodium glutamate: oxidative stress and metabolic shifting in hepatic tissue [DOI]
  21. 21 Late effects of postnatal administration of monosodium glutamate on insulin action in adult rats.
  22. 22 Role of the Kidney in the Metabolism of Fructose in 60-hour Fasted Humans [DOI]
  23. 23 Excitotoxins in foods.
  24. 24 Plant glutathione S-transferases and herbicide detoxification.
  25. 25 Prolonged glutamate excitotoxicity: Effects on mitochondrial antioxidants and antioxidant enzymes [DOI]
  26. 26 Hypothalamic mechanisms mediating glutamate effects on the hypothalamo-pituitary-adrenocortical axis [DOI]
  27. 27 Renal oxygen consumption, thermogenesis, and amino acid utilization during i.v. infusion of amino acids in man [DOI]
  28. 28 Effects of oral monosodium ( l )‐glutamate on insulin secretion and glucose tolerance in healthy volunteers [DOI]
  29. 29 Important role of the kidney in human carbohydrate metabolism [DOI]
  30. 30 Chronic Administration of Monosodium Glutamate under Chronic Variable Stress Impaired Hypothalamic-Pituitary-Adrenal Axis Function in Rats [DOI]
  31. 31 Some biochemical effects of sub-acute oral administration of L-arginine on monosodium glutamate-fed Wistar albino rats 1: body weight changes, serum cholesterol, creatinine, and sodium ion concentrations [DOI]
  32. 32 Studies on effect of monosodium glutamate (MSG) on various fractions of lipids and certain carbohydrate metabolic enzymes in liver and blood of adult male mice [DOI]
  33. 33 Glucose production by the human kidney - its importance has been underestimated [DOI]
  34. 34 PHOSPHATASES OF LIVER [DOI]
  35. 35 An improved glucose-oxidase method for determining blood C.S.F. and urine glucose levels [DOI]
  36. 36 Central but not peripheral glucoprivation is impaired in monosodium glutamate-treated rats [DOI]
  37. 37 Glutathione status, lipid peroxidation and kidney function in streptozotocin diabetic rats [DOI]
  38. 38 The Effects Of Monosodium Glutamate On The Open Field Locomotor Activities In Adult Wistar Rats [DOI]

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