MicroRNAs and Their Role in Bone Remodeling and Pathogenesis
Ajai Singh, Sabir Ali, Abbas Ali Mahdi, Rajeshwar Nath Srivastava
Journal of Advances in Medicine and Medical Research · pp. 727–749 · Published 23 Nov 2012
10.9734/BJMMR/2012/1543Abstract
MicroRNAs, a class of post-transcriptional gene expression regulators that bind to complementary sequences in the 3’ UTR or 5’ UTR of mRNAs have recently been detected in human body fluids including peripheral blood plasma as extracellular nuclease resistant entities. It is now clear that the biogenesis and functions of microRNAs are related to the molecular mechanisms of various clinical diseases and they can potentially regulate every aspect of cellular activity. This review will highlight our current understanding of microRNA biogenesis and their mechanisms of action. It will also summarize recent works on the role of microRNAs in bone remodeling including angiogenesis, osteoblast and osteoclast differentiation and in various bone related pathologies. An in-depth understanding of the roles of these regulatory mRNAs in the skeleton will be critical for the development of new therapeutics aimed on bone remodeling including fracture repair and bone-related diseases.
References (119)
- 1 MicroRNAs [DOI]
- 2 The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans [DOI]
- 3 MicroRNAs Modulate Hematopoietic Lineage Differentiation [DOI]
- 4 Principles of MicroRNA–Target Recognition [DOI]
- 5 bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila [DOI]
- 6 MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies [DOI]
- 7 Embryonic Stem Cell-Specific MicroRNAs [DOI]
- 8 Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. [DOI]
- 9 The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism [DOI]
- 10 Short RNAs Repress Translation after Initiation in Mammalian Cells [DOI]
- 11 Biological functions of microRNAs: a review [DOI]
- 12 Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation [DOI]
- 13 MicroRNA control of bone formation and homeostasis [DOI]
- 14 Physiology and pathophysiology of bone remodeling.
- 15 MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo [DOI]
- 16 Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs [DOI]
- 17 miRNA Signatures Associate with Pathogenesis and Progression of Osteosarcoma [DOI]
- 18 Glimpses of a Tiny RNA World [DOI]
- 19 The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis [DOI]
- 20 A Runx2/miR-3960/miR-2861 Regulatory Feedback Loop during Mouse Osteoblast Differentiation [DOI]
- 21 miR‐210 promotes osteoblastic differentiation through inhibition of AcvR1b [DOI]
- 22 MiR-133a in Human Circulating Monocytes: A Potential Biomarker Associated with Postmenopausal Osteoporosis [DOI]
- 23 MicroRNA biogenesis and regulation of bone remodeling [DOI]
- 24 miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1 [DOI]
- 25 miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3 [DOI]
- 26 MicroRNAs regulate osteogenesis and chondrogenesis [DOI]
- 27 Brief Report: Amelioration of collagen‐induced arthritis in mice by lentivirus‐mediated silencing of microRNA‐223 [DOI]
- 28 Identification of Committed Mononuclear Precursors for Osteoclast-Like Cells Formed in Long Term Human Marrow Cultures* [DOI]
- 29 Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain [DOI]
- 30 Bone lining cells: structure and function.
- 31 MicroRNA hsa-miR-135b Regulates Mineralization in Osteogenic Differentiation of Human Unrestricted Somatic Stem Cells [DOI]
- 32 Identification of MicroRNAs Inhibiting TGF-β-Induced IL-11 Production in Bone Metastatic Breast Cancer Cells [DOI]
- 33 MicroRNAs in Chondrogenesis, Articular Cartilage, and Osteoarthritis: Implications for Tissue Engineering [DOI]
- 34 Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation [DOI]
- 35 Angiogenic microRNA‐210 is present in cells surrounding osteonecrosis [DOI]
- 36 MicroRNA signature associated with osteogenic lineage commitment [DOI]
- 37 Expression of BMP‐2 and Ets1 in BMP‐2‐stimulated mouse pre‐osteoblast differentiation is regulated by microRNA‐370 [DOI]
- 38 Ibandronate promotes osteogenic differentiation of periodontal ligament stem cells by regulating the expression of microRNAs [DOI]
- 39 MicroRNAs and their roles in osteoclast differentiation [DOI]
- 40 The Microphthalmia Transcription Factor Regulates Expression of the Tartrate-Resistant Acid Phosphatase Gene During Terminal Differentiation of Osteoclasts [DOI]
- 41 MiR-9 promotes the neural differentiation of mouse bone marrow mesenchymal stem cells via targeting zinc finger protein 521 [DOI]
- 42 The Regulatory Network Menin-MicroRNA 26a As a Possible Target for RNA-Based Therapy of Bone Diseases [DOI]
- 43 Concerted stimuli regulating osteo-chondral differentiation from stem cells: phenotype acquisition regulated by microRNAs [DOI]
- 44 Anatase Nanosurface Regulates MicroRNAs [DOI]
- 45 Do microRNAs regulate bone marrow stem cell niche physiology? [DOI]
- 46 MicroRNAs in skeletogenesis [DOI]
- 47 Medpor® regulates osteoblast's microRNAs [DOI]
- 48 Bioinformatic analysis of microRNA biogenesis and function related proteins in eleven animal genomes [DOI]
- 49 From selenoprotein to endochondral ossification: A novel mechanism with microRNAs potential in bone related diseases? [DOI]
- 50 Osteoclast Biology and Bone Resorption [DOI]
- 51 The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 [DOI]
- 52 Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets [DOI]
- 53 Circulating microRNAs as stable blood-based markers for cancer detection [DOI]
- 54 Mesenchymal stem cells [DOI]
- 55 miRBase: microRNA sequences, targets and gene nomenclature [DOI]
- 56 Nuclear Export of MicroRNA Precursors [DOI]
- 57 TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing [DOI]
- 58 miR-126 Regulates Angiogenic Signaling and Vascular Integrity [DOI]
- 59 Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR [DOI]
- 60 The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation [DOI]
- 61 Osteogenesis and angiogenesis: The potential for engineering bone [DOI]
- 62 Salivary microRNA: Discovery, Characterization, and Clinical Utility for Oral Cancer Detection [DOI]
- 63 microPrimer: the biogenesis and function of microRNA [DOI]
- 64 Mammalian Mirtron Genes [DOI]
- 65 A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer [DOI]
- 66 Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis [DOI]
- 67 The Mechanism Selecting the Guide Strand from Small RNA Duplexes is Different Among Argonaute Proteins [DOI]
- 68 An mRNA m7G Cap Binding-like Motif within Human Ago2 Represses Translation [DOI]
- 69 A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans [DOI]
- 70 Proposal for the regulatory mechanism of Wolff's law [DOI]
- 71 miR-29 Modulates Wnt Signaling in Human Osteoblasts through a Positive Feedback Loop [DOI]
- 72 Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation [DOI]
- 73 Distance constraints between microRNA target sites dictate efficacy and cooperativity [DOI]
- 74 Numerous microRNPs in neuronal cells containing novel microRNAs [DOI]
- 75 Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs [DOI]
- 76 Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells Is Modulated by the miR-26a Targeting of the SMAD1 Transcription Factor [DOI]
- 77 A microRNA regulatory mechanism of osteoblast differentiation [DOI]
- 78 RNAi‐based therapeutics–current status, challenges and prospects [DOI]
- 79 A microRNA expression signature of osteoclastogenesis [DOI]
- 80 miRNA-34c regulates Notch signaling during bone development [DOI]
- 81 Impaired Micro-RNA Pathways Diminish Osteoclast Differentiation and Function [DOI]
- 82 MiR-637 maintains the balance between adipocytes and osteoblasts by directly targeting Osterix [DOI]
- 83 MicroRNA‐223 is a key factor in osteoclast differentiation [DOI]
- 84 Identification of Multiple Osteoclast Precursor Populations in Murine Bone Marrow [DOI]
- 85 miR-30 Family Members Negatively Regulate Osteoblast Differentiation [DOI]
- 86 Functional Profiling Reveals Critical Role for miRNA in Differentiation of Human Mesenchymal Stem Cells [DOI]
- 87 Osteoclast‐specific Dicer gene deficiency suppresses osteoclastic bone resorption [DOI]
- 88 miR-20a Encoded by the miR-17–92 Cluster Increases the Metastatic Potential of Osteosarcoma Cells by Regulating Fas Expression [DOI]
- 89 Down-Regulation of miR-183 Promotes Migration and Invasion of Osteosarcoma by Targeting Ezrin [DOI]
- 90 MicroRNA Involvement in Osteosarcoma [DOI]
- 91 MicroRNAs miR‐96, miR‐124, and miR‐199a regulate gene expression in human bone marrow‐derived mesenchymal stem cells [DOI]
- 92 Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma [DOI]
- 93 MECHANISMS IN ENDOCRINOLOGY: Micro-RNAs: targets for enhancing osteoblast differentiation and bone formation [DOI]
- 94 miR-93/Sp7 function loop mediates osteoblast mineralization [DOI]
- 95 MicroRNA-34a modulates genes involved in cellular motility and oxidative phosphorylation in neural precursors derived from human umbilical cord mesenchymal stem cells [DOI]
- 96 Death of osteocytes turns off the inhibition of osteoclasts and triggers local bone resorption [DOI]
- 97 Rethinking the Microprocessor [DOI]
- 98 Differential expression of components of the microRNA machinery during mouse organogenesis [DOI]
- 99 Manipulation of miRNA activity accelerates osteogenic differentiation of hMSCs in engineered 3D scaffolds [DOI]
- 100 Cis -regulation of microRNA expression by scaffold/matrix-attachment regions [DOI]
- 101 Characterization of extracellular circulating microRNA [DOI]
- 102 The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis [DOI]
- 103 A microRNA array reveals extensive regulation of microRNAs during brain development [DOI]
- 104 miR-148 targets human DNMT3b protein coding region [DOI]
- 105 Potent effect of target structure on microRNA function [DOI]
- 106 Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone [DOI]
- 107 MicroRNA markers for forensic body fluid identification obtained from microarray screening and quantitative RT-PCR confirmation [DOI]
- 108 Structural determinants of miRNAs for RISC loading and slicer-independent unwinding [DOI]
- 109 Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells. [DOI]
- 110 miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2 [DOI]
- 111 Calcitonin Receptors as Markers for Osteoclastic Differentiation: Correlation between Generation of Bone-Resorptive Cells and Cells that Express Calcitonin Receptors in Mouse Bone Marrow Cultures* [DOI]
- 112 Structure-function relationships in the osteocyte.
- 113 Anorganic bovine bone and a silicate-based synthetic bone activate different microRNAs [DOI]
- 114 Immunolocalization of beta 3 subunit of integrins in osteoclast membrane.
- 115 Cathepsin K in aseptic hip prosthesis loosening: expression in osteoclasts without polyethylene wear particles.
- 116 [Screening of differentially expressed microRNAs in bone marrow-derived mesenchymal stem cells during osteoporosis and their function in stem cell differentiation]. [DOI]
- 117 [miRNAs in cartilage development].
- 118 [Novel regulatory mechanism of bone metabolism].
- 119 [Role of microRNAs on regulation of bone and cartilage tissue].
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