Pathogenesis of the Influenza Virus in Diabetes Model Mice
Morihiro Ito, Hiromichi Kubota, Tamaki Takeuchi, Shanlou Qiao, Masato Tsurudome, Hideki Tsumura, Akio Matsuda, Yasuhiko Ito, Machiko Nishio
Microbiology Research Journal International · pp. 1–7 · Published 23 Jul 2015
10.9734/BMRJ/2015/18799Abstract
When diabetes model mice and control mice were intranasally infected with the influenza virus (1 LD50), a significant higher mortality rate was observed in the diabetes model. The mortality rate became 100% at 10 days post infection. Furthermore, histopathological examination of lung tissue revealed a more enhanced inflammatory response in the diabetes model mice infected with the influenza virus. On the contrary, viral clearance from the lungs was suppressed in the diabetes model mice. The recruitment of macrophages was observed in the case of virus-infected control mice at 1 and 3 days post infection. Intriguingly, the number of macrophage in the lungs was not changed through the period of observation, thus the recruitment of macrophages in the lungs was not found in the virus-infected diabetes model mice.
Cited by 3
Rebekah Honce, Nicholas Wohlgemuth, Victoria A. Meliopoulos · Cold Spring Harbor Perspectives in Medicine · 2019
R. Ammar, Karim Montasser, H. Ezz · Journal of Medical Virology · 2019
Katina D Hulme, L. Gallo, K. R. Short · Frontiers in Microbiology · 2017
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