Ischaemia Modified Albumin and Malondialdehyde Level in Subjects Suffering from Hypothyroidism

Abstract

Thyroid hormone deficiency (hypothyroidism) leads to many serious conditions in body. Oxidative stress (OS), a state of excess free radicals and reactive metabolites formation which ultimately leads to an imbalance between the production of oxidants and their elimination by antioxidative systems in the body. Researchers all around the globe are in search of the link between this oxidative stress by estimating its different markers and hypothyroidism. In this present study oxidative stress is evaluated in hypothyroidism by estimating serum ischaemia modified albumin (IMA) and malondialdehyde (MDA). Settings and Design: 56 patients attending different Out-Patient Department (OPD) who have fulfilled inclusion criteria were included as cases and 43 apparently healthy persons were selected as control. Serum fT4 and TSH level measured by immunoassay and serum IMA and MDA level measured by well standardised validated methods. Results: By undertaking independent sample‘t’ test it is found that mean and standard deviation (SD) of IMA (t=4.149, p<0.001) and MDA (t=19.171, p<0.001) are significantly increased in case group than the control group. In case group it was found that serum IMA & MDA are significantly correlated with fT4 {r= -0.835 (IMA) & -0.765(MDA)} & TSH {(r= +0.859(IMA) & +0.672(MDA)}.