Anti Colton-A Foeto-Neonatal Haemolytic Disesase:  Diagnosis; Clinical Outcome  and Family Study

G. Gessoni; L. Collodel; I. Vaccara; M. Pivetta; T. Mancuso; P. Lago; A. Cattarozzi; N. Revelli; A. Barzan; P. Cavicchioli

doi:10.9734/ibrr/2023/v14i1299

Research Article Open access CC BY 4.0

Anti Colton-A Foeto-Neonatal Haemolytic Disesase: Diagnosis; Clinical Outcome and Family Study

G. Gessoni, L. Collodel, I. Vaccara, M. Pivetta, T. Mancuso, P. Lago, A. Cattarozzi, N. Revelli, A. Barzan, P. Cavicchioli

International Blood Research & Reviews · pp. 29–37 · Published 27 Jan 2023

10.9734/ibrr/2023/v14i1299

Abstract

The authors report a case of neonatal haemolytic disease (HDN) attributable to maternal allo immunization to a high frequency antigen present on paternal red blood cells which have been identified as Colton-a (Coa). The case seemed worthy of reporting not only for the relative rarity of HDN from anti Coa but for the rigorous approach followed in the immunohaematological follow-up of pregnancy and for the diagnostic effort expended in identifying the specificity of the antibody. A family study of ascendants, collaterals and descendants was also carried out using genotyping techniques.

Anti-Coa family study genotyping HDFN

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G. Gessoni, L. Collodel, I. Vaccara, M. Pivetta, T. Mancuso, P. Lago, A. Cattarozzi, N. Revelli, A. Barzan, P. Cavicchioli (2023). Anti Colton-A Foeto-Neonatal Haemolytic Disesase: Diagnosis; Clinical Outcome and Family Study. International Blood Research & Reviews , 29–37. https://doi.org/10.9734/ibrr/2023/v14i1299

Affiliations

G. Gessoni — ULSS 3 Serenissima, Transfusion Medicine Department, Dell’Angelo General Hospital, Mestre, Venice, Italy.
L. Collodel — ULSS 3 Serenissima, Transfusion Medicine Department, Dell’Angelo General Hospital, Mestre, Venice, Italy.
I. Vaccara — ULSS 3 Serenissima, Transfusion Medicine Department, Dell’Angelo General Hospital, Mestre, Venice, Italy.
M. Pivetta — ULSS 3 Serenissima, Transfusion Medicine Department, Dell’Angelo General Hospital, Mestre, Venice, Italy.
T. Mancuso — IMMUCOR Italia SPA Research and Development, Mialn, Italy.
P. Lago — ULSS 2 Marca Trevigiana, Intensive Neonatal Care, Ca’ Foncello General Hospitale, Treviso, Italy.
A. Cattarozzi — ULSS 3 Serenissima, Pediatric Unit, Madonna della Navicella Hospital, Chiogga, Venice, Italy.
N. Revelli — Transfusion Medicine Department, Policlinico Hospital, Milano, Italy.
A. Barzan — ULSS 2 Marca Trevigiana Transfusion Medicine Department, Ca’ Foncello General Hospital, Treviso, Italy.
P. Cavicchioli — ULSS 3 Serenissima, Pediatric and Neonatal Unit, Dell’Angelo General Hospital. Mestre, Venice, Italy.

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