Effect of Silver Nanoparticles Synthesized from Azadirachta indica Leaves Extract on Sickle Erythrocyte Membrane Stability
Mustapha Isah, Sumayya Ahmed Ayuba
Asian Journal of Biochemistry, Genetics and Molecular Biology · pp. 1–6 · Published 5 Jan 2022
10.9734/ajbgmb/2022/v10i130233Abstract
Aim: To synthesize silver nanoparticles (AgNPs) from Azadirachta indica leaf extract and determine its effect on membrane stability. Place and Duration of Study: Department of Biochemistry, Sokoto State University, Sokoto, Nigeria, between January 2021 and April 2021. Methodology: Simple characterization using uv-vis spectroscopy was conducted and the well-known method for osmotic fragility was employed. Results: Surface plasmon excitation for conversion of Ag+ to AgNPs was successfully achieved at 320 nm. The result revealed increase in membrane stability with 67.50 % for sickle erythrocyte (HbSS), 33.33 % for carrier erythrocyte (HbAS) and 23.33 % for normal erythrocyte (HbAA); thereby decreasing the erythrocyte lysis in the order of HbSS>HbAS>HbAA. Conclusion: AgNPs synthesized from A. indica reduces osmotic fragility and hence increases membrane stabilizing potential particularly against sickle erythrocyte.
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