Investigating the Role of Microbial Biofilms in Antimicrobial Resistance and Developing Novel Strategies for Eradication
Ohaekwe Conlethann Chiemerie, Nwodo Amaka Marvellous, Amina Suleiman Kamsalem, Jenyo Yetunde Elizabeth, Iyiola Aanuoluwa Temitayo, Victor Ekoche Ali, Matthew Taiye Moses
South Asian Journal of Research in Microbiology · pp. 46–54 · Published 20 May 2025
10.9734/sajrm/2025/v19i6441Abstract
The study investigates the role of microbial biofilms in antimicrobial resistance and explores novel eradication strategies. Microbial biofilms, structured communities of bacteria encased in an extracellular polymeric substance, significantly contribute to persistent infections by enhancing bacterial tolerance to antibiotics and immune responses. The review highlights the mechanisms underlying biofilm-associated resistance, including limited antibiotic penetration, metabolic dormancy, and genetic exchange. Conventional treatments often fail against biofilms, necessitating innovative approaches such as quorum sensing inhibitors, bacteriophage therapy, and nanotechnology-based drug delivery systems. By synthesizing current research, this study underscores the urgent need for novel interventions to combat biofilm-related infections and mitigate antimicrobial resistance.
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