Influence of Diaminazene Aceturate (Berenil®) on the Haematology of Yankasa Sheep Experimentally  Infected with Trypanosoma evansi

A. M. Bello; H. Abdulsalam; J. Dauda; A. W. Mbaya; A. U. Mani

doi:10.9734/ajravs/2023/v6i4264

Research Article Open access CC BY 4.0

Influence of Diaminazene Aceturate (Berenil®) on the Haematology of Yankasa Sheep Experimentally Infected with Trypanosoma evansi

A. M. Bello, H. Abdulsalam, J. Dauda, A. W. Mbaya, A. U. Mani

Asian Journal of Research in Animal and Veterinary Sciences · pp. 380–393 · Published 13 Oct 2023

10.9734/ajravs/2023/v6i4264

Abstract

Haematological profiles were determined in Yankasa sheep experimentally infected with Trypanosoma evansi (T. evansi) and treated with diaminazene aceturate (berenil®). A total of 30 animals were divided into 6 groups (A to F) (n=5). Animals from each group were either uninfected or infected with T. evansi, and treated with Berenil®. Infection of the infected groups (A, C and E) was done via intravenous inoculation of T. evansi, while the infected group C and E were treated with berenil® at 3.5 and 7 mg/kg BW, respectively, by day 16 post infection (PI). The infected groups had pre-patent period of 8 days, with similar levels of parasitaemia (4.7 ± 0.27). In group A, the mean parasite count rose significantly (P < 0.05) to 72.8 ± 1.07 by day 12 PI and continue to a peak value of 250.6 ± 1.98 by day 28 PI. In group C and E, the initial parasitaemia rose significantly (P < 0.05) to 80.8 ± 1.12 and 78.2 ± 1.11 by day 12 PI, following treatment with 3.5 and 7.0 mg/kg BW of berenil®, by day 20 PI, respectively, and was completely eliminated by day 9 and 5 post treatment (PT), respectively. As parasitaemia increased, PCV, RBC, Hb, WBC, platelets count, absolute lymphocytes and monocytes, significantly declined (P<0.05) in group A, leading to anaemia at day 16 PT. It is therefore, demonstrated that both the two doses of berenil® were effective in the treatment of the disease under experimental conditions but 7.0 mg/kg cleared the parasitaemia faster.

Diaminazene aceturate Experimental Haematology Trypanosoma evansi Yankasa breed of sheep

References (14)

1 District Laboratory Practice in Tropical Countries [DOI]
2 Tropical animal health and production [DOI]
3 Veterinary clinical pathology [DOI]
4 Control and surveillance of African trypanosomiasis [DOI]
5 Study on Bovine Trypanosomiasis and Associated Risk Factors in Benatsemay District, Southern Ethiopia [DOI]
6 The rapid development of drug-resistance by Trypanosoma evansi in immunosuppressed mice [DOI]
7 Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model [DOI]
8 Seroprevalence of Trypanosoma evansi in camels using CATT/T. evansi technique in Borno and Yobe states, Nigeria [DOI]
9 Variation of sensitivity of Trypanosoma evansi isolates from Isiolo and Marsabit counties of Kenya to locally available trypanocidal drugs [DOI]
10 Systematic Review and Meta-Analysis on Knowledge Attitude and Practices on African Animal Trypanocide Resistance [DOI]
11 Management of Camel Trypanosomiasis (Surra) among Pastoralists of Isiolo and Marsabit Counties, Kenya [DOI]
12 Effects of experimental Trypanosoma evansi infection on pregnancy in Yankasa ewes [DOI]
13 Role of erythrocyte surface sialic acid in inducing anaemia in Savannah Brown bucks experimentally infected with Trypanosoma evansi
14 Clinicopathological and Microscopic Features of Trypanosoma brucei and Trypanosoma evansi Induced Infections in Sheep II [DOI]

Cited by 0

No indexed citations yet.

Changes in Liver Histomorphology, Hematological Parameters and Lipid Profile of Cadmium-Exposed Rats Treated with Combined Leaf Extract of Vernonia amygdalina and Occimum gratissimum — shares topic coverage
Haemato-biochemical Alterations and Significance of Prognostic Indicators in Dogs with Canine Parvoviral Infection — shares topic coverage
Study of Some Haematological Parameters of Japanese Quail (Coturnix coturnix japonica) Experimentally Infected with Salmonella enterica Serovar Gallinarum — shares topic coverage
Haematological and Biochemical Changes Associated with Treatment of Experimentally-Induced Hypertensive Wistar Rats with Lagenaria breviflora Roberty Fruit or Xanthosoma sagittifolium Exell Corm — shares topic coverage
Response of Broiler Chickens to Carica papaya and Talinium triangulare Leaf Meal under Normal and Subnormal Diets — shares topic coverage

Access this article

View at publisher

Cite this article

A. M. Bello, H. Abdulsalam, J. Dauda, A. W. Mbaya, A. U. Mani (2023). Influence of Diaminazene Aceturate (Berenil®) on the Haematology of Yankasa Sheep Experimentally Infected with Trypanosoma evansi. Asian Journal of Research in Animal and Veterinary Sciences , 380–393. https://doi.org/10.9734/ajravs/2023/v6i4264

Affiliations

A. M. Bello — Department of Veterinary Medicine, University of Maiduguri, Nigeria.
H. Abdulsalam — Department of Veterinary Pathology, University of Maiduguri, Nigeria.
J. Dauda — Department of Veterinary Public Health and Preventive Medicine, University of Maiduguri, Nigeria.
A. W. Mbaya — Department of Veterinary Parasitology and Entomology, University of Maiduguri, Nigeria.
A. U. Mani — Department of Veterinary Medicine, University of Maiduguri, Nigeria.

Metrics

53
Views: 0
Downloads: 0
Citations: 8
Outbound

Full metrics

Article metrics

Real usage data collected on this platform.

53

Page views

0

PDF downloads

8

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.