Impact of AstraZeneca COVID-19 Vaccination on Coagulation and Gene Expression: A Molecular and Clinical Study
Erens Spiff Ekprikpo, Stella Urekweru Ken-Ezihuo, Beauty Eruchi Echonwere-uwikor, Zaccheaus Awortu Jeremiah
International Journal of Research and Reports in Hematology · pp. 111–119 · Published 23 Apr 2025
10.9734/ijr2h/2025/v8i1171Abstract
This case-control study investigated the effects of the AstraZeneca COVID-19 vaccine on coagulation parameters in a cohort of 102 individuals, revealing a significant increase in activated partial thromboplastin time (aPTT) among vaccinated individuals (34.233±0.653 seconds vs 28.196±0.657 seconds, p<0.0001), which correlated with increased TMPRSS2 expression (r=-0.325, p=0.0202). The findings have important clinical implications, suggesting that vaccinated individuals, particularly those with underlying coagulopathies, may require closer monitoring for thrombotic events. The observed changes in aPTT and TMPRSS2 expression may have significant implications for patients with pre-existing coagulation disorders or those at risk of thrombotic events, emphasizing the need for vigilant monitoring and personalized care in vaccinated individuals, and highlighting the importance of further research to inform evidence-based guidelines for COVID-19 vaccination.
Cited by 0
No indexed citations yet.
Related research
- Evaluation of Plasma Fibrinogen Level, Platelet Count & Lipid Profile as Predictors of Cardiovascular Disease among Bangladeshi Healthy Male Smokers — shares topic coverage
- Coagulation Parameters among Women with Obstetric Complications in Specialist Hospital Sokoto, Nigeria — shares topic coverage
- Coagulation Parameters among Individuals with Hepatitis B Infections in Okada, Edo State, Nigeria — shares topic coverage
- Physician Burnout and Associated Factors: Orthopaedics vs Anesthesia — shares topic coverage
- Nursing Strategies in Diabetes Mellitus Management: A Comprehensive Review of Patient-centred Care and Technological Innovation — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.