Peptides Corresponding to Intracellular Regions of GPCR as a New Generation of Selective Drugs
International Journal of Biochemistry Research & Review · pp. 380–400 · Published 21 Aug 2013
10.9734/IJBCRR/2013/5593Abstract
In the G protein-coupled receptors (GPCRs) relatively short regions of their intracellular loops and cytoplasmic C-terminal domain are responsible for specific interaction with G-proteins. GPCR-derived peptides corresponding to these regions are able to influence the activity of signal pathways involving the cognate receptors. Modified by hydrophobic radicals, these peptides turn into their cell-penetrating analogs, pepducins, possessing the activity both in vitro and in vivo. This review is devoted to the analysis of the available data and the prospects for GPCR-peptides and their lipophilic derivatives to be used in experimental and clinical medicine in the treatment of vascular diseases, cancers, inflammation, and endocrine dysfunctions.
Cited by 3
A. O. Shpakov, K. V. Derkach · Journal of Evolutionary Biochemistry and Physiology · 2015
K. V. Derkach, E. A. Shpakova, A. O. Shpakov · Bulletin of Experimental Biology and Medicine · 2014
A. O. Shpakov, E. A. Shpakova, I. I. Tarasenko · Cell and Tissue Biology · 2014
Related research
- Does Pain Adversely Affect the Quality of Life in Hospitalized Cancer Patients? — shares topic coverage
- Complementary Medicine Intervention in Breast Cancer Patients with Pain — shares topic coverage
- Use of Performance Status Score for Cytotoxic Chemotherapy among Surgeons in a Tertiary Hospital, Southern Nigeria — shares topic coverage
- Breast Self Examination and Cancer Awareness among Female Staff in Federal Medical Center, Yenagoa, Bayelsa State (Knowledge and Practice) — shares topic coverage
- Assessment of Cancer Risk from Fluorscopic Bile Duct Examinations at Sanjiwani Hospital, Gianyar — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
3
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.