Alexander O. Shpakov

Peptides Corresponding to Intracellular Regions of GPCR as a New Generation of Selective Drugs

Alexander O. Shpakov · International Journal of Biochemistry Research & Review · 2013

In the G protein-coupled receptors (GPCRs) relatively short regions of their intracellular loops and cytoplasmic C-terminal domain are responsible for specific interaction with G-proteins. GPCR-derived peptides corresponding to these regions are able to influence the activity of...

Open access Research Article 10.9734/IJBCRR/2013/5593

Hormonal Sensitivity of Adenylyl Cyclase in the Myocardium, Brain and Testes of 18-month-old Non-Diabetic and Diabetic Rats

Alexander O. Shpakov, Kira V. Derkach, Irina V. Moyseyuk, Oxana V. Chistyakova & Vera M. Bondareva · International Journal of Biochemistry Research & Review · 2013

The alterations and abnormalities in hormone-sensitive adenylyl cyclase (AC) system occur at early stages of the type 2 diabetes mellitus (T2DM) and at later stages of the disease they are, according to our view, one of the factors causing T2DM complications. To study the changes...

Open access Research Article 10.9734/IJBCRR/2013/2833