Human Tumor Necrosis Factor-α as a Diagnostic Marker for Chronic Diabetic Nephropathy
Khalid Ibrahem Husein Al Ghodran, Amina Ali Dessouki, Heba M. A. Abdelrazek, Dahlia Ibrahim Badran, Emad M. Gad
International Journal of Biochemistry Research & Review · pp. 522–529 · Published 12 Dec 2024
10.9734/ijbcrr/2024/v33i6933Abstract
Background: diabetic nephropathy (DN) is a chronic main microvascular consequence of untreated hyperglycemia, affects a significant portion of the population. It's thought to be the main factor causing end-stage kidney disease. TNF-α is involved in the development and course of disease in DN. Aim: This study aimed to evaluate plasma TNF-α as a new diagnostic marker for early DN. Patients and Methods: This study included 125 Egyptian subjects attending the out Patients Clinic of the Department of Internal Medicine, 10Th of Ramadan city Health Insurance Hospital and divided as follow:- Control group , Study groups( patient with diabetic mellitus (DM),DN, DN and other complications). Control& study group were subjected to measurement of glycosylated hemoglobin (HbA1C), creatinine, total cholesterol, triglycerides, F.B.G, GFR ,HDL, LDL, ALT, AST, total protein, albumin, globulin, A/G ratio, HDL, LDL, ACR,TNF-α. Results: results showed that plasma TNF-α was positive and significantly correlated with BMI, duration of DM, F.B.G, HbAIC, CR, GFR, CHOL, HDL, LDL, AST, A/G ratio, Meanwhile, plasma TNF-α was negatively correlated with ACR, TG, ALT, ALB, TP and GLB. At cut-off level ≥83.5, TNF-α had 96.7% sensitivity and 79.7% specificity for diagnosing diabetic nephropathy. Conclusion: The study found that patients in study group had considerably higher plasma levels of TNF-α. This suggests that TNF-α May be used as a markers for predicting chronic DN in patients with type 2 diabetes.
References (2)
- 1 Assessment of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Retinol-Binding Protein 4 (RBP4) in Type 2 Diabetic Patients with Nephropathy [DOI]
- 2 Impact of isolated high home systolic blood pressure on diabetic nephropathy in patients with type 2 diabetes mellitus: A 5-year prospective cohort study [DOI]
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A. Ishag, Daris Adouma, Almoeiz Y Hammad · Journal of Integrated Health Sciences · 2025
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