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Green Synthesis of Silver and Zinc Oxide Nanoparticles Using Post-harvest Leaves of Vigna subterranean and their Antimicrobial, Anti-inflammatory and Antioxidant Potentials

Adaora Stella Ogbuagu, Lilian Chinelo Innocent, Nkeoma Nkasi Okoye, Sophina Ogonna Umeh, Josephat Okechukwu Ogbuagu

Asian Journal of Applied Chemistry Research · pp. 1–14 · Published 24 Apr 2023

10.9734/ajacr/2023/v13i3243

Abstract

Green route synthesis of nanoparticles has been known to be beneficial as one of the non-toxic methods of synthesizing potential drugs. The aqueous extracts of Vigna subterranean (Bambara nut) leaves discarded after harvest were used in the synthesis of silver and zinc nanoparticles using 1mM concentration of silver nitrate (AgNO3) and zinc oxide (Zn O) respectively. The nanoparticles were characterized using Ultraviolet-Visible (UV/Vis) Spectroscopy, Fourier-Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM) and X-ray Diffraction Analysis (XRD). Antibacterial and antifungal studies were conducted on two strains of bacteria (Salmonella typhi. and Staphylococcus aureus) and two strains of fungi (Aspergillus niger and Aspergillus flavus) based on their inhibition zone diameter using paper disk diffusion methods. Anti-inflammatory and antioxidant studies were also conducted on the nanoparticles using the inhibition of protein denaturation and reduction of DPPH respectively. The λmax absorption of the nanoparticles were found to be 434 and 460 nm respectively in the UV/Vis region. Their shapes and nature were spherical and amorphous as confirmed by the SEM and XRD analysis. The diameters of the nanoparticles ranged from 20 to 60 nm using the Particle metric particle analysis software. The FTIR confirmed the presence of some bioactive functional groups involved in the reduction of AgNO3 and Zn O to Ag and Zn nanoparticles. The nanoparticles showed moderate activities against the tested bacterial strains while showing no activity against the fungi strain when compared with standard drugs. They however showed strong anti- inflammatory and antioxidant activities. The silver and zinc mediated nanoparticles could serve as a potential source for antioxidants and anti-inflammatory drugs.

Green synthesis nanoparticles anti-inflammatory antioxidant

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Cited by 1

Role of Banbara Nuts as Nutraceutical and its Potential in Green Synthesis of Nanoparticles: Ability of Bioactive Compounds

Joseph P Shaba, Amusan TO, Evans C Egwim · International Journal of Advanced Biochemistry Research Noosphere · 2025

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