GC-MS Profile, α-glucosidase Inhibition Potential, Antibacterial and Antioxidant Evaluation of Peels Citrus aurantium (L), Essential Oil
Hafedh Hajlaoui, Soumaya Arraouadi, Kaïss Aouadi, Mejdi Snoussi, Emira Noumi, Adel Kadri
Journal of Pharmaceutical Research International · pp. 1580–1591 · Published 23 Dec 2021
10.9734/jpri/2021/v33i60B34781Abstract
This study was designed to analyze the chemical composition of Citrus aurantium Essential Oil (CAEO) peels and to evaluate α-glucosidase inhibition potential, antioxidant and antibacterial activities. According to GC-MS analyses, 37 compounds were identified with limonene was the most abundant (62.2%). Majority of the identified compounds belong to hydrocarbon monoterpenes fraction (75.7%), followed by oxygenated monoterpenes (19.16%). CAEO α-glucosidase inhibition outlined an important activity with IC50 = 10±1 mg/mL. Moreover, antioxidant activity revealed that CAEO exhibited a potent scavenging effect through 2,2-diphenyl-1 picrylhydrazyl radical (DPPH.) (IC50=33.66 µg/mL) and an important ferric ion reducing antioxidant power (FRAP) activity (EC50=98.67 µg/mL). Antimicrobial data demonstrate that CAEO was active against a panel of pathogenic bacteria and that CAEO was able to destroy bacterial cells (bactericidal) according to the MBC/MIC ratios towards Gram+ and Gram- tested strains.
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