Formulation and in vitro Evaluation of a Novel Gastroretentive Gas-Generating Floating Matrix Tablets of Domperidone

Abstract

Aim and Objective: Domperidone floating matrix tablets were developed to increase the drug's bioavailability by prolonging its stomach residence time. These systems aim to provide controlled release, enhanced bioavailability, and improved patient compliance compared to conventional systems, especially for drugs with prolonged gastric residence. Methodology: The wet granulation method was employed in formulating the tablets, utilizing polymers such as carboxymethylcellulose and carbopol. Various physical attributes of the tablets, including hardness, thickness, friability, weight variation, FTIR, XRD, drug content, and floating properties, were evaluated. Furthermore, the 12-hour in vitro drug release properties of the tablets were examined. Results: As the tablets floated in the dissolving medium, they exhibited extended and sustained drug release characteristics. It was established that the drug release mechanism from these tablets followed Fickian diffusion, highlighting the crucial roles played by polymer rearrangement and water diffusion in the process of drug release. The choice of the optimal formulation (F3) was based on its in vitro characteristics. Conclusion: The investigations conducted affirmed that the tablets are poised to deliver the intended therapeutic effects while maintaining an optimal residence time in the stomach, coupled with prolonged drug release.