Extract of Edible Seafood - Egeria Radiata (Clam) Boosts Blood Parameters in Rats
A. N. Archibong, O. E. Ofem, A. A. Akwari, S. U. Ukweni, A. E. Eno, F. N. Beshel
Current Journal of Applied Science and Technology · pp. 1684–1692 · Published 20 Feb 2014
10.9734/BJAST/2014/6612Abstract
Aims: This study investigates the effect of consumption of an edible seafood - Egeria Radiata (Clam) on hematological parameters in rats. Study Design: Albino Wistar rats were assigned to 3 groups of 5 rats each. Place and Duration of Study: Department of Physiology, University of Calabar, Nigeria. Methodology: The protein content of the extract was estimated as 24.60±.1mg protein / mL. Graded doses of the extract (1.64 – 104.96mg protein / kg) were administered (i.p) in rats to determine the LD50 value of the extract. Based on the LD50 value (56.36mg/kg), two test doses (low dose - 7.0 mg protein / mL and high dose - 52mg protein / mL) were selected and administered to two groups of rats orally and daily for six weeks, while a third group of rats served as the control, n = 5. Blood samples were obtained from all the rats via cardiac puncture for the analysis of the various hematological indices. Results: Both the low and high doses of the extract produced significant increases in RBC count (P<.001), Hb (P<.001) and PCV (P<.001) compared with control. MCH (P<.001), MCHC (P<.001), total WBC count (P<.001) and platelet count (P<.001) were also increased in the extract groups. The extract groups had significant reductions in mean platelet volume (P<.001), platelet distribution width (P<.001) and platelet large cell ratio (P<.001) compared with control. Conclusion: In conclusion, an edible molluscan sea animal (Clam) probably contains food substances that enhance erythropoiesis, leukocytosis and thrombopoiesis. Clam could therefore serve as preferred and stable supplementary diets.
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