Evaluation of Thrombolytic Effect of Seven Different Bangladeshi Plants
Mohammed Abdullah Jainul, Shofiul Azam, Amin Chowdhury, Mohammad Mamun Ur Rashid, Abdullah Al Mamun, Hasibul Quader Chowdhury
Journal of Pharmaceutical Research International · pp. 1400–1406 · Published 31 May 2014
10.9734/BJPR/2014/6854Abstract
Aim: From time past till date, proper documentation of the use of medicinal plants are helpful in drug development and research. The objective of this study is to evaluate several plant extracts of Bangladesh for their thrombolytic activity. Study Design: There are seven different plants from unlike families were studied in this primary research work. They were collected between August-September (2012) and the thrombolytic effect of their extractions was investigated. Streptokinase was used as standard to compare with and evaluate the significance of each result. Result: Among all studied plants Gardenia coronaria showed most promising result of 49.61±0.866% of lysis, whereas streptokinase exhibited a lysis of 75.36±0.964%. The extracts of Hedychium thyrsiforme and Artocarpus chaplasha showed also promising activity with 48.39±1.813% and 43.69±0.906% of thrombolytic effect, respectively. Conclusion: All the plants used in this study showed promising thrombolytic activity compared to standard. Proper phytochemical characterization and isolation of the constituent compounds responsible for this activity may be further investigated and could be a future source of lead thrombolytic compounds.
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Shofiul Azam, Prawej Ansari, Mohammad Mamun Ur Rashid · Biomedical Research and Therapy · 2015
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