Skip to content
Research Article Open access CC BY 4.0

Evaluation of Serum Levels of Some Water-Soluble Vitamin B Complexes in Cardiovascular Disease Patients

Nkeiruka Chigekwu Mbadiwe, Uchechi Maryrose Michael, Prince Henry Nnadi, Chidiebere Ikechukwu Ikaraoha, Chizaram Winners Ndubueze, Vivian Ihechikwadorom Njoku

International Journal of Biochemistry Research & Review · pp. 135–142 · Published 29 Jul 2024

10.9734/ijbcrr/2024/v33i7896

Abstract

This study was carried out to investigate the serum levels of water-soluble vitamin B complexes (vitamin B3, vitamin B6, vitamin B9 and vitamin B12) in patients with cardiovascular diseases attending Cardiac Clinic at ESUTH Enugu State. Blood samples were obtained using the venipuncture technique from twenty cardiovascular disease patients, consisting of ten male and ten female patients. They were aged-matched with ten male and ten female controls, respectively. The serum concentrations of vitamins B3, B6, B9 and B12 were estimated using the titration methods for B3 and B6 and spectrophotometric methods for B9 and B12, respectively, and data generated were subjected to statistical analysis. The results showed that the serum concentrations of vitamin B6, B12 and B9 were significantly higher (p=0.000, p=0.000 and p=0.004, respectively) in cardiovascular disease patients compared to controls. Furthermore, there was no significant difference in serum concentration of vitamin B3 (p=0.274) in cardiovascular disease patients compared to controls. Similarly, there were no significant differences in serum concentrations of vitamin B3, B6 and B9 (p=0.810, p=0.650, and p=0.478, respectively) in male cardiovascular disease patients compared to the females. On the other hand, the serum concentration of vitamin B12 was significantly lower (p= 0.012) in male patients compared to females. The correlation analysis showed that there was a significant positive correlation of vitamin B3 with B6 (r=0.564, p=0.010), whereas no significant correlation of vitamin B3 with B12 and B9 (r=0.137, p= 0.565 and r= -0.392, p=0.088 respectively) in cardiovascular disease patients. These results suggest that higher doses of these vitamins may play a role in reducing cardiovascular disease complications.

Heart diseases niacin pyridoxine folic acid cobalamin

References (28)

  1. 1 Epidemiology of Heart Failure [DOI]
  2. 2 Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men [DOI]
  3. 3 Pearson's Composition and Analysis of Foods
  4. 4 The Global Burden of Disease Study and the Preventable Burden of NCD [DOI]
  5. 5 Tryptophan-kynurenine pathway is dysregulated in inflammation and immune activation [DOI]
  6. 6 Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts [DOI]
  7. 7 Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta‐Analysis of Randomized Controlled Trials [DOI]
  8. 8 Disorders of riboflavin metabolism [DOI]
  9. 9 Vitamin E and Cardiovascular Disease [DOI]
  10. 10 A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk [DOI]
  11. 11 Is Vitamin B12 Deficiency a Risk Factor for Cardiovascular Disease in Vegetarians? [DOI]
  12. 12 High-dose Parenteral Thiamine in Treatment of Wernicke’s Encephalopathy: Case Series and Review of the Literature [DOI]
  13. 13 Effectiveness of Some Vitamins in the Prevention of Cardiovascular Disease: A Narrative Review [DOI]
  14. 14 Features, Symptoms, and Neurophysiological Findings in Stroke Associated With Hyperhomocysteinemia [DOI]
  15. 15 Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins? [DOI]
  16. 16 Novel metabolic disturbances in marginal vitamin B6-deficient rat heart [DOI]
  17. 17 Intakes of folate, vitamin B6, and vitamin B12 and cardiovascular disease risk: a national population-based cross-sectional study [DOI]
  18. 18 Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery disease [DOI]
  19. 19 Plasma homocysteine and menopausal status** [DOI]
  20. 20 TABERʼS CYCLOPEDIC MEDICAL DICTIONARY [DOI]
  21. 21 Vitamin D deficiency and heart disease [DOI]
  22. 22 Vitamin C Deficiency, High-Sensitivity C-Reactive Protein, and Cardiac Event-Free Survival in Patients With Heart Failure [DOI]
  23. 23 The role of folic acid in deficiency states and prevention of disease.
  24. 24 How can cobalamin injections be spaced in long-term therapy for inborn errors of vitamin B12 absorption? [DOI]
  25. 25 Effect of folic acid, vitamin B12, and B6 supplementation on the risk of cardiovascular and cerebrovascular diseases: An updated meta-analysis of randomized controlled trials [DOI]
  26. 26 Vitamin E Supplementation Improves Oxidant-antioxidant Balance in Chronic Renal Failure Patients Treated by Hemodialysis [DOI]
  27. 27 Water-Soluble Vitamins [DOI]
  28. 28 Cardiovascular Diseases (CVDs) [DOI]

Cited by 2

Vitamin B6 nutrition, metabolism, and the relationship of diseases: current concepts and future research

Yue Zhao, Xiaoli Liu, Rubing Li · Journal of Future Foods · 2026

Showing 1 of 2 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

20

Page views

0

PDF downloads

3

Outbound clicks

2

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.