Elucidation of Anti-hyperlipidemic Activity of 70% Ethanolic Extract of Coccinia grandis on High Fat-induced Hyperlipidaemic Wister Albino Rat Model

Abstract

The practice of utilizing herbs and herbal remedies to prevent, treat, or cure diseases, as well as to maintain and promote maximum health, is known as herbalism. In certain areas, people may confuse herbal medicine with treatments. Among the leading causes of mortality globally, atherosclerotic cardiovascular disease (ASCVD) and its long-term effects are particularly notable. Adolescents who have atherosclerosis are at progressively higher risk of cardiac events, including heart disease, myocardial infarction (MI), and stroke, throughout later life. This research examined the effects of a Coccinia grandis extract on lipid profiles in rats with high-fat-induced hyperlipidemia When the rats with high fat diet were administered dosage of 900 mg/kg, respectively, the SGPT and SGOT levels in group 6 showed statistically significant results (p<0.05). Statistical analysis during the renal function test showed that the doses of creatinine in groups 5 and 6, which received 600 and 900 mg/kg CG extract, respectively, were substantially different (p<0.05). The urea analysis provided statistically significant result in group 6. Taking into account high-density lipoprotein (HDL) and low-density lipoprotein (LDL), group 6 had statistically significant outcomes (p<0.05) in HDL and LDL levels where the given dose was 900 mg/kg. Triglyceride levels in Group 6 differed statistically significantly (p < 0.05). When it came to total cholesterol levels, Group 6, which received a dosage of 900 mg/kg, showed statistically significant results (p<0.05). Coccinia grandis extract has the potential to be an effective medicinal plant in the treatment of hyperlipidemia.