Effect of Enzyme Replacement Therapy on Disease Burden Biomarkers in Gaucher's Disease
Mohammed H. Hassan, Ayat A. Sayed, Ahmed El-Abd Ahmed, Tahia H. Saleem, Khalid I. Elsayh, Norhan B. B. Mohammed
International Journal of Biochemistry Research & Review · pp. 1–6 · Published 26 Jan 2017
10.9734/IJBCRR/2016/30768Abstract
Aims: We evaluate the effect of enzyme replacement therapy "ERT" on the plasma levels of some biochemical markers of the disease burden, in pediatric patients with Gaucher's disease "GD", in the form of plasma chitotriosidase "ChT", total acid phosphatase activity, ferritin and globulin to evaluate the therapeutic monitoring efficacy of such biomarkers. Methodology: A cross sectional case control study, carried out on 26 GD pediatric patients, divided into group A (13): On ERT and group B (13): Not receiving ERT, and in addition to 20 healthy age and sex matched controls. ELISA assays of plasma ChT and ferritin, colorimetric assays of plasma total acid phosphatase activity and globulin, were done for all groups, while, plasma proteins electrophoresis was done for GD patients only. Results: Significant higher plasma levels of ChT, total acid phosphatase activity, ferritin and globulin among GD not receiving ERT versus both GD on ERT and Control group. Positive correlation between plasma ferritin and total acid phosphatase activity (r = 0.465 and P-value <0.05). Conclusions: Plasma ChT, total acid phosphatase activity; ferritin and globulin are collectively helpful in evaluation and follow up the effect of ERT.
References (11)
- 1 Gaucher disease: pathological mechanisms and modern management [DOI]
- 2 Gaucher disease: haematological presentations and complications [DOI]
- 3 Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature [DOI]
- 4 Hyperferritinemia and iron overload in type 1 Gaucher disease [DOI]
- 5 Value of plasma chitotriosidase to assess non‐neuronopathic Gaucher disease severity and progression in the era of enzyme replacement therapy [DOI]
- 6 Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases [DOI]
- 7 Correlation of surrogate markers of Gaucher disease. Implications for long-term follow up of enzyme replacement therapy [DOI]
- 8 Biomarkers in Serbian patients with Gaucher disease [DOI]
- 9 Immunoglobulin abnormalities and effects of enzyme replacement therapy in children with Gaucher disease [DOI]
- 10 Electron microscopic study on acid phosphatase of macrophages during the breakdown of erythrocytes in the spleen of the rat [DOI]
- 11 Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment [DOI]
Cited by 4
Mohammed H. Hassan, Ayat A. Sayed, Ahmed El-Abd Ahmed, Tahia H. Saleem · International Journal of Biochemistry Research & Review · 2017
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