Skip to content
Research Article Open access CC BY 4.0

Effect of Enzyme Replacement Therapy on Disease Burden Biomarkers in Gaucher's Disease

Mohammed H. Hassan, Ayat A. Sayed, Ahmed El-Abd Ahmed, Tahia H. Saleem, Khalid I. Elsayh, Norhan B. B. Mohammed

International Journal of Biochemistry Research & Review · pp. 1–6 · Published 26 Jan 2017

10.9734/IJBCRR/2016/30768

Abstract

Aims: We evaluate the effect of enzyme replacement therapy "ERT" on the plasma levels of some biochemical markers of the disease burden, in pediatric patients with Gaucher's disease "GD", in the form of plasma chitotriosidase "ChT", total acid phosphatase activity, ferritin and globulin to evaluate the therapeutic monitoring efficacy of such biomarkers.  Methodology: A cross sectional case control study, carried out on 26 GD pediatric patients, divided into group A (13): On ERT and group B (13): Not receiving ERT, and in addition to 20 healthy age and sex matched controls. ELISA assays of plasma ChT and ferritin, colorimetric assays of plasma total acid phosphatase activity and globulin, were done for all groups, while, plasma proteins electrophoresis was done for GD patients only. Results: Significant higher plasma levels of ChT, total acid phosphatase activity, ferritin and globulin among GD not receiving ERT versus both GD on ERT and Control group. Positive correlation between plasma ferritin and total acid phosphatase activity (r = 0.465 and P-value <0.05). Conclusions: Plasma ChT, total acid phosphatase activity; ferritin and globulin are collectively helpful in evaluation and follow up the effect of ERT.

Disease burden markers Gaucher's disease ERT

References (11)

  1. 1 Gaucher disease: pathological mechanisms and modern management [DOI]
  2. 2 Gaucher disease: haematological presentations and complications [DOI]
  3. 3 Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature [DOI]
  4. 4 Hyperferritinemia and iron overload in type 1 Gaucher disease [DOI]
  5. 5 Value of plasma chitotriosidase to assess non‐neuronopathic Gaucher disease severity and progression in the era of enzyme replacement therapy [DOI]
  6. 6 Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases [DOI]
  7. 7 Correlation of surrogate markers of Gaucher disease. Implications for long-term follow up of enzyme replacement therapy [DOI]
  8. 8 Biomarkers in Serbian patients with Gaucher disease [DOI]
  9. 9 Immunoglobulin abnormalities and effects of enzyme replacement therapy in children with Gaucher disease [DOI]
  10. 10 Electron microscopic study on acid phosphatase of macrophages during the breakdown of erythrocytes in the spleen of the rat [DOI]
  11. 11 Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment [DOI]

Cited by 4

Diagnostic Utility of Plasma Chitotriosidase, Total Acid Phosphatase Activity, Ferritin and Globulin Levels in Screening for Gaucher Disease

Mohammed H. Hassan, Ayat A. Sayed, Ahmed El-Abd Ahmed, Tahia H. Saleem · International Journal of Biochemistry Research & Review · 2017

The Role of Liver Function Tests in Monitoring the effect of Enzyme Replacement Therapy in Children with Gaucher Disease

Haidar A. Abdulamir, Ameer A A Aldafaay, Ahmed Hamza Al-Shammari · Research Journal of Pharmacy and Technology · 2022

Showing 2 of 4 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

46

Page views

0

PDF downloads

30

Outbound clicks

4

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.