Effect of Aqueous Extract of Dodonaea viscosa Linn on Some Biochemical Parameters in Alloxan-induced Diabetic Rats

Abstract

This study evaluates the effect aqueous leaf extracts Dodonaea viscosa Linn on alloxan-induced diabetic rats. Sixty grams of Dodonaea viscosa Linn leaf that has initially been pulverized was used to produce the aqueous extract. Sixteen male albino rats were randomly divided into four groups of four rats per group. Three groups were induced with experimental diabetes using alloxan monohydrate at a graded dose of 150 mg/kg body weight. Group A rats were given feed and water; Group B rats were not given any form of treatment for 14 days. Group C rats were treated with Dodonaea viscosa Linn extract at 400 mg/kg body weight for 14 days. Group D rats were treated with metformin at 400 mg/kg body weight for 14 days. All administration were done orally through intragastric tube method. At the end of 14 days, blood samples of all rats in each group were collected for liver function test, lipid profile, kidney function test and uric acid. The results obtained were analyzed statistically using a one way analysis of variance (ANOVA) tool at p<0.05. Results of the analysis showed that aqueous leaf extract of Dodonaea viscosa Linn is a potential candidate for the management of diabetic mellitus and its associate complications.