Bone Metastasis of Urothelial Carcinoma

Abstract

Background: Bone metastasis of urothelial carcinoma is the third most common metastasis after the lungs and liver. Bone complications adversely affect the quality of life. They are also associated with increased mortality. The objective of this study is to describe the epidemiological, clinical and prognostic aspects of bone metastasis  of urothelial carcinoma Materials and Methods: This is a retrospective, monocentric study of 8 cases of bone metastases of urothelial carcinoma, collected from January 2018 to September 2020 at the Ibn Rochd University Hospital in Casablanca, Morocco. The analyzed data were collected on an exploitation sheet. Incomplete records were excluded from the study. Results: The average age of our patients was 61.37 years. All the  patients  were male  and smokers. Pain was the main calling sign and was marked  in seven patients. Four patients had anemia and 50% of the patients had acute obstructive kidney disease. CT scanning of the body  was requested to all the patients and confirmed bone metastasis in seven patients with predominantly osteolytic lesions. The treatment was palliative and consisted of chemotherapy, radiotherapy or combined therapy. Among them,three patients  died, two of them progressed to have  new lesions and three others had stabilized lesions. Conclusion: The presence of bone metastasis of urothelial carcinoma constitutes an unfavorable moment in the evolution of this cancer. These metastases are responsible for many complications that require multidisciplinary management.