Diagnostic Performance of Faecal Calprotectin among People with Chronic Inflammatory Diseases of the Bowel in Cameroon: A Pilot Study in  Sub-Saharan Africa

Irina Lydia Sudeu Nitcheu; Thomas Djifack Tadongfack; Falmata Amazia; Melissa Guechoun Choundong; Marthe Pelagie Alogo; Paul Talla; Batakeh B. Agoons; Vicky Jocelyne Ama Moor

doi:10.9734/ijbcrr/2021/v30i530264

Research Article Open access CC BY 4.0

Diagnostic Performance of Faecal Calprotectin among People with Chronic Inflammatory Diseases of the Bowel in Cameroon: A Pilot Study in Sub-Saharan Africa

Irina Lydia Sudeu Nitcheu, Thomas Djifack Tadongfack, Falmata Amazia, Melissa Guechoun Choundong, Marthe Pelagie Alogo, Paul Talla, Batakeh B. Agoons, Vicky Jocelyne Ama Moor

International Journal of Biochemistry Research & Review · pp. 1–10 · Published 4 Sep 2021

10.9734/ijbcrr/2021/v30i530264

Abstract

Background: Inflammatory bowel diseases (IBDs) are relatively common in African countries. The use of faecal markers, Calprotectin in particular, is presently of considerable interest to IBD patients. The high faecal calprotectin level has a good diagnostic accuracy in discriminating intestinal organic and functional diseases and enables the selection of patients in need of other invasive diagnosis such as endoscopy. Aim: To evaluate the diagnostic performance of faecal calprotectin as a useful diagnostic tool for IBD patients in Cameroon. Study design: This was a case control cross-sectional multicentre study conducted in major gastroenterology units of the towns of Yaoundé and Douala involving 64 participants grouped as 32 IBD positive subjects and 32 IBD negative subjects. Methods: Stool sample collected from participants at various recruitment sites were collected, conditioned and transported to the CIAB laboratory for analysis using a direct ELISA method. The R software was used for data analysis. Results: The calprotectin levels of IBD patients were significantly higher than those of the control subjects (P < .001.) The area under the curve (AUC) was 0.96 [95%CI: 0.92 – 1.00; P < .001]. A threshold value of 2.51µg/g was chosen to exclude the diagnosis of IBD with an 87.5% sensitivity and 100% specificity. The CRP levels correlated with those of calprotectin (r꞊0.579, P ꞊ .005). Calprotectin concentrations became abnormally elevated in all UC patients with an Endoscopy Score greater than or equal to 6 (P = .001). Correlation between the endoscopy score for Crohn's disease and calprotectin concentration did not retain significance (ρ꞊0.800; P > .05). Conclusion: Calprotectin dosage is a sensitive test for IBD, excludes unnecessary investigations and accurately predicts disease recurrence and response to treatment.

IBD Crohn’s disease Haemorrhagic rectocolitis Calprotectin

References (6)

1 Assessment of the Neutrophil Dominating Protein Calprotectin in Feces: A Methodologic Study [DOI]
2 Recent trends in the epidemiology of inflammatory bowel diseases: Up or down [DOI]
3 Diagnostic Precision of Fecal Calprotectin for Inflammatory Bowel Disease and Colorectal Malignancy [DOI]
4 Fecal Markers: Calprotectin and Lactoferrin [DOI]
5 Value of fecal calprotectin in the evaluation of patients with abdominal discomfort: an observational study [DOI]
6 Prise en charge des maladies inflammatoires chroniques de l’intestin : JAK is back! [DOI]

Cited by 1

Diagnostic Value of Faecal Calprotectin in Children with Chronic Gastrointestinal Disorders at Yaounde General Hospital

M. Isabelle, Audrey Ngo, Nkeck Pascal · American Journal of Pediatrics · 2024

Possible Effects of Moringa oleifera versus Ginger (Zingiber officinalis) on Experimental Colitis in Mice — shares topic coverage
Rare Association of Eagle Syndrome with Crohn’s Disease — shares topic coverage
Unmet Communication and Information Needs for Patients with IBD: Implications for Mobile Health Technology — shares topic coverage
Exploring the Pathogenic Role of Stress in Inflammatory Bowel Disease and its Management — shares topic coverage
Serum Level of Calprotectin in Juvenile Idiopathic Arthritis and Its Correlation with Disease Activity Clinicaland Ultrasonographic — shares topic coverage

Access this article

View at publisher

Cite this article

Irina Lydia Sudeu Nitcheu, Thomas Djifack Tadongfack, Falmata Amazia, Melissa Guechoun Choundong, Marthe Pelagie Alogo, Paul Talla, Batakeh B. Agoons, Vicky Jocelyne Ama Moor (2021). Diagnostic Performance of Faecal Calprotectin among People with Chronic Inflammatory Diseases of the Bowel in Cameroon: A Pilot Study in Sub-Saharan Africa. International Journal of Biochemistry Research & Review , 1–10. https://doi.org/10.9734/ijbcrr/2021/v30i530264

Affiliations

Irina Lydia Sudeu Nitcheu — Immunology Department, School of Health Sciences, Catholic university of Central Africa, Yaoundé. P. O. Box: 1110 Yaoundé-Cameroon.
Thomas Djifack Tadongfack — Medical Laboratory Unit, Saint Vincent de Paul Hospital Dschang P. O. Box: 11 Dschang-Cameroon.
Falmata Amazia — Department of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I P. O. Box: 2787 Yaoundé-Cameroon.
Melissa Guechoun Choundong — Immunology Department, School of Health Sciences, Catholic university of Central Africa, Yaoundé. P. O. Box: 1110 Yaoundé-Cameroon.
Marthe Pelagie Alogo — Gastroenterology Department, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I P. O. Box: 2787 Yaoundé-Cameroon.
Paul Talla — Gastroenterology Department, Yaoundé General Hospital. P. O. Box: 1364 Yaoundé-Cameroon.
Batakeh B. Agoons — Department of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I P. O. Box: 2787 Yaoundé-Cameroon.
Vicky Jocelyne Ama Moor — Department of Biochemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I P. O. Box: 2787 Yaoundé-Cameroon.

Metrics

34
Views: 0
Downloads: 1
Citations: 4
Outbound

Full metrics

Article metrics

Real usage data collected on this platform.

34

Page views

0

PDF downloads

4

Outbound clicks

1

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.