Comparative Evaluation of Anti-diabetic Potential of Aqueous Seed Extracts of Momordica charantia, Seed Kernel Extract of Mangifera indica and Its Herbal Formulation – an in vitro Study

Abstract

Introduction: A condition in which the body’s ability gets impaired to process blood glucose level is called diabetes, otherwise known as blood sugar. It ranked sixteenth among leading causes of death around the globe. There are estimated 72.96 million cases diagnosed with diabetes in the adult population of India. Momordica charantia possess anti-diabetic, anti hyperglycemic and anti inflammatory properties. Mangifera indica is traditionally used to treat diarrhoea, cancer, diabetes and tooth aches. Aim: Aim of this study is to analyse comparative evaluation of anti-diabetic potential of aqueous seed extracts of Momordica charantia, seed kernel extract of Mangifera indica through in vitro analysis. Methods: Momordica charantia and Mangifera indica were collected from local farms, and the extracts were analysed for its phytochemicals. Antioxidant and Anti-diabetic potential of the seed extract were evaluated along with standards. The data were analysed statistically by a one way analysis of variance (ANOVA) followed by Duncan’s multiple range test was used to see the statistical significance among the groups. The results with the p<0.05 level were considered to be statistically significant. Results: Momordica charantia and Mangifera indica and its herbal formulation showed significant antioxidant and anti-diabetic potential. Conclusion: The results showed both the seed and seed kernel extracts of Momordica charantia and Mangifera indica possessed anti-diabetic activity but the herbal formulation possessed much more significant anti-diabetic activity than the individual extract.