Chemical and Antihyperglycemic Evaluation of Detoxified Rubber Kernel Oil from Hevea (Hevea brasiliensis)

Abstract

The characteristic study of cyanide-detoxified rubber tree kernels revealed a rubber tree oil with interesting nutritional and therapeutic profiles. Analyses showed that the oil is rich in antioxidants, essential fatty acids, and vitamins (A, E, and B). Most of these compounds, particularly antioxidants and essential fatty acids, are known for their ability to promote homeostasis and blood sugar regulation in hyperglycaemic individuals. This would be an advantage for this plant material, with a view to further promoting its use in the treatment of metabolic diseases such as type II diabetes, given that rubber tree seeds are readily available in Côte d'Ivoire. The aim of this study was to evaluate the effect of detoxified rubber tree kernel oil on blood sugar levels. The effect of rubber tree seed oil on blood sugar levels was evaluated in normoglycaemic and hyperglycaemic rats. The results of the extract's effect on blood sugar levels showed that the extract did not cause hypoglycaemia or hyperglycaemia in normoglycaemic rats. As for the effect of the extract on blood sugar levels in hyperglycaemic rats, the extract caused a significant reduction in glucose-induced hyperglycaemia in rats. The use of this plant in the treatment of hyperglycaemia would therefore be justified, given the proven sensitivity of the antioxidants and fatty acids in rubber tree seeds to insulin.