Testicular Teratoma with Metastatic Somatic Malignant Transformation:  A Rare Case Report

M. Belaghzal; Y. Retal; Z. Bakkali Aissaoui; A. Khallouk

doi:10.9734/ajrru/2026/v9i1158

Research Article Open access CC BY 4.0

Testicular Teratoma with Metastatic Somatic Malignant Transformation: A Rare Case Report

M. Belaghzal, Y. Retal, Z. Bakkali Aissaoui, A. Khallouk

Asian Journal of Research and Reports in Urology · pp. 101–109 · Published 24 Apr 2026

10.9734/ajrru/2026/v9i1158

Abstract

Background: Somatic malignant transformation (SMT) in testicular teratomas is a rare phenomenon and is associated with relative resistance to chemotherapy, making therapeutic management particularly challenging. Case Report: A 69-year-old man presented with a large left testicular mass associated with para-aortic lymphadenopathy. Radical orchiectomy revealed a teratoma with somatic malignant transformation, including adenocarcinomatous, sarcomatous, and neuroectodermal components. Following BEP chemotherapy (bleomycin, etoposide, and cisplatin), the persistence of a residual lymph node mass led to a retroperitoneal lymph node dissection (RPLND). Histopathological examination revealed a pure residual teratoma. Conclusion: This case highlights the prognostic value of histological analysis of residual masses and emphasizes the central role of surgery in metastatic forms with somatic malignant transformation.

Testicular neoplasms teratoma somatic malignant transformation germ cell tumor retroperitoneal lymph node dissection neoplasm metastasis

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M. Belaghzal, Y. Retal, Z. Bakkali Aissaoui, A. Khallouk (2026). Testicular Teratoma with Metastatic Somatic Malignant Transformation: A Rare Case Report. Asian Journal of Research and Reports in Urology , 101–109. https://doi.org/10.9734/ajrru/2026/v9i1158

Affiliations

M. Belaghzal — Department of Urology, Mohammed VI University Hospital, Tangier, Morocco.
Y. Retal — Department of Urology, Mohammed VI University Hospital, Tangier, Morocco.
Z. Bakkali Aissaoui — Department of Urology, Mohammed VI University Hospital, Tangier, Morocco.
A. Khallouk — Department of Urology, Mohammed VI University Hospital, Tangier, Morocco.

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