Biophysical Study for the Interactions of Some Diazo Dyes with Human Serum Albumin
Mohammed Hadi Al–Douh, Elham Abdalrahem Bin Selim, Edrees Muhammad Tahir, Sabah Ahmed Abdo Esmail, Yaman Ahmed Naji, Hassan Hadi Abdullah
Asian Journal of Applied Chemistry Research · pp. 1–10 · Published 28 Dec 2019
10.9734/ajacr/2019/v4i330113Abstract
The biophysical interactions between the human serum albumin HSA and three synthesized diazo dyes 1-3 have been investigated by thermodynamic parameters and molecular docking technique. The binding constants Kb were calculated and the compounds were ranked according to their docking free energy. Different interactions were elucidated at the active site of the protein. Among these interactions is the hydrogen bonding which plays an essential role in the interaction with the protein. Both the theoretical and practical studies have agreed that diazo dye 1 has the strongest interaction with the active site.
References (14)
- 1 Thermodynamics of protein association reactions: forces contributing to stability [DOI]
- 2 Crystal structure of human serum albumin at 2.5 Å resolution [DOI]
- 3 Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands [DOI]
- 4 VEGA – An open platform to develop chemo-bio-informatics applications, using plug-in architecture and script programming [DOI]
- 5 Crystal structural analysis of human serum albumin complexed with hemin and fatty acid [DOI]
- 6 Specific antioxidant properties of human serum albumin [DOI]
- 7 Synthesis, characterization and interaction studies of copper based drug with Human Serum Albumin (HSA): Spectroscopic and molecular docking investigations [DOI]
- 8 Exploring docking and aerobic-microaerophilic biodegradation of textile azo dye by bacterial systems [DOI]
- 9 Influence of auxochrome group in disperse dyes bearing azo groups as chromophore center in the biotransformation and molecular docking prediction by reductase enzyme: Implications and assessment for environmental toxicity of xenobiotics [DOI]
- 10 DNA interaction, docking, molecular modelling and biological studies of o-Vanillin derived Schiff base metal complexes [DOI]
- 11 Design, synthesis and characterization of tin‐based cancer chemotherapy drug entity: In vitro DNA binding, cleavage, induction of cancer cell apoptosis by triggering DNA damage‐mediated p53 phosphorylation and molecular docking [DOI]
- 12 A novel recombinant AzrC protein proposed by molecular docking and in silico analyses to improve azo dye's binding affinity [DOI]
- 13 2-Substituted Aniline as a Simple Scaffold for LuxR-Regulated QS Modulation [DOI]
- 14 Heterobimetallic o-vanillin functionalized complexes: In vitro DNA binding validation, cleavage activity and molecular docking studies of CuII–Sn2IV analogs [DOI]
Cited by 4
Mohammed Hadi Al–Douh, Elham Abdalrahem Bin Selim, Hassan Hadi Abdallah, Hewa Y. Abdullah, Aisha Khalid Al–Bakri, Dahab Salim Al–Nohey, Samia Mabrook Bin Mahram, Khulood Mahfoudh Yusr, Faten Abdulaziz Bin Hawiel · Asian Journal of Applied Chemistry Research · 2021
Elham Abdalrahem Bin Selim, Mohammed Hadi Al–Douh, H. H. Abdullah · Asian Journal of Applied Chemistry Research · 2021
Mohammed Hadi Al–Douh, Elham Abdalrahem Bin Selim, Haydar A. Mohammad Salim · 2019 First International Conference of Intelligent Computing and Engineering (ICOICE) · 2019
Elham Abdalrahem Bin Selim, Mohammed Hadi Al-Douh, Samia Mabrook Bin Mahram · 2022
Related research
- Glycosylated Antibiotics: New Promising Bacterial Efflux Pumps Inhibitors — shares topic coverage
- Integrating In-silico and In-vitro Approaches to Screen the Antidiabetic Drug from Trigonella foenum graecum Linn. — shares topic coverage
- Structural Mapping of Inhibitors Binding Sites on P-glycoprotein: Mechanism of Inhibition of P-Glycoprotein by Herbal Isoflavones — shares topic coverage
- Azamacrocycle Complexes: Synthesis and Xanthine Oxidase and Antioxidant Activity — shares topic coverage
- Evaluation of Selected Natural Compounds for Cancer Stem Cells Targeted Anti-cancer Activity: A Molecular Docking Study — shares topic coverage
Article metrics
Real usage data collected on this platform.
21
Page views
0
PDF downloads
1
Outbound clicks
4
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.