Structural Mapping of Inhibitors Binding Sites on P-glycoprotein: Mechanism of Inhibition of P-Glycoprotein by Herbal Isoflavones

References (60)

1. 1 Improved methods for building protein models in electron density maps and the location of errors in these models [DOI]
2. 2 Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy [DOI]
3. 3 Dietary Intake and Bioavailability of Polyphenols [DOI]
4. 4 Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2) [DOI]
5. 5 The E. coli BtuCD Structure: A Framework for ABC Transporter Architecture and Mechanism [DOI]
6. 6 Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.
7. 7 Crystal structure of a catalytic intermediate of the maltose transporter [DOI]
8. 8 Structure of an ABC transporter in complex with its binding protein [DOI]
9. 9 β‐Amyloid efflux mediated by p‐glycoprotein [DOI]
10. 10 Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells. [DOI]
11. 11 An Inward-Facing Conformation of a Putative Metal-Chelate-Type ABC Transporter [DOI]
12. 12 Quercetin potentiates the effect of Adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target [DOI]
13. 13 Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response [DOI]
14. 14 Effect of quercetin on hoechst 33342 transport by purified and reconstituted p-glycoprotein [DOI]
15. 15 Interaction of macrocyclic lactones with P-glycoprotein: Structure–affinity relationship [DOI]
16. 16 Predicting Binding to P-Glycoprotein by Flexible Receptor Docking [DOI]
17. 17 Human P-Glycoprotein Exhibits Reduced Affinity for Substrates during a Catalytic Transition State [DOI]
18. 18 Isoprenylated flavonoids—a survey [DOI]
19. 19 Three-dimensional Structures of the Mammalian Multidrug Resistance P-glycoprotein Demonstrate Major Conformational Changes in the Transmembrane Domains upon Nucleotide Binding [DOI]
20. 20 Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein [DOI]
21. 21 Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3) [DOI]
22. 22 Role of P-Glycoprotein Inhibition for Drug Interactions [DOI]
23. 23 Nucleotide-induced Structural Changes in P-glycoprotein Observed by Electron Microscopy [DOI]
24. 24 Multidrug Resistance Reversal and Apoptosis Induction in Human Colon Cancer Cells by Some Flavonoids Present in Citrus Plants [DOI]
25. 25 Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1. [DOI]
26. 26 Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters [DOI]
27. 27 8-Prenylnaringenin is an inhibitor of multidrug resistance-associated transporters, P-glycoprotein and MRP1 [DOI]
28. 28 Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain [DOI]
29. 29 Effects of Sertraline and Fluoxetine on P-Glycoprotein at Barrier Sites: In Vivo and In Vitro Approaches [DOI]
30. 30 Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: In vitro and in vivo [DOI]
31. 31 Oroxylin A reverses P-glycoprotein-mediated multidrug resistance of MCF7/ADR cells by G2/M arrest [DOI]
32. 32 Parguerenes: Marine red alga bromoditerpenes as inhibitors of P-glycoprotein (ABCB1) in multidrug resistant human cancer cells [DOI]
33. 33 Stilbenes as multidrug resistance modulators and apoptosis inducers in human adenocarcinoma cells.
34. 34 Multidrug Resistance in Cancer [DOI]
35. 35 Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages [DOI]
36. 36 Effect of quercetin on P-glycoprotein transport ability in Chinese healthy subjects [DOI]
37. 37 In Vivo Inhibition of BCRP/ABCG2 Mediated Transport of Nitrofurantoin by the Isoflavones Genistein and Daidzein: A Comparative Study in Bcrp1 −/− Mice [DOI]
38. 38 Potent and Fully Noncompetitive Peptidomimetic Inhibitor of Multidrug Resistance P-Glycoprotein [DOI]
39. 39 Can flavonoids from honey alter multidrug resistance? [DOI]
40. 40 Reversal of P-glycoprotein-mediated multidrug resistance is induced by mollugin in MCF-7/adriamycin cells [DOI]
41. 41 Reversal of P-glycoprotein-mediated multidrug resistance by a synthetic α-aminoxy peptidomimetic [DOI]
42. 42 Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes [DOI]
43. 43 Molecular Modeling Correctly Predicts the Functional Importance of Phe594 in Transmembrane Helix 11 of the Multidrug Resistance Protein, MRP1 (ABCC1) [DOI]
44. 44 2D- and 3D-QSAR studies of a series of benzopyranes and benzopyrano[3,4b][1,4]-oxazines as inhibitors of the multidrug transporter P-glycoprotein [DOI]
45. 45 Homology modeling and structural analysis of human P-glycoprotein [DOI]
46. 46 Influence of the multidrug transporter P-glycoprotein on the intracellular pharmacokinetics of vandetanib [DOI]
47. 47 Inhibition of P-glycoprotein-mediated transport by S-adenosylmethionine and cynarin in multidrug-resistant human uterine sarcoma MES-SA/Dx5 cells.
48. 48 The biology of the P-glycoproteins [DOI]
49. 49 Reversal effect of rosmarinic acid on multidrug resistance in SGC7901/Adr cell [DOI]
50. 50 Loxapine P-glycoprotein Interactions In Vitro [DOI]
51. 51 Coot : model-building tools for molecular graphics [DOI]
52. 52 Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [DOI]
53. 53 Mammalian ABC Transporters in Health and Disease [DOI]
54. 54 Structure of a bacterial multidrug ABC transporter [DOI]
55. 55 Uses and Properties ofCitrusFlavonoids [DOI]
56. 56 Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents [DOI]
57. 57 Amine Linked Flavonoid Dimers as Modulators for P-Glycoprotein-Based Multidrug Resistance: Structure–Activity Relationship and Mechanism of Modulation [DOI]
58. 58 Inhibitory Effects of Herbal Extracts on Breast Cancer Resistance Protein (BCRP) and Structure-Inhibitory Potency Relationship of Isoflavonoids [DOI]
59. 59 Polyphenols Counteract Tumor Cell Chemoresistance Conferred by Multidrug Resistance Proteins [DOI]
60. 60 Effects of detergents on P-glycoprotein atpase activity: differences in perturbations of basal and verapamil-dependent activities.

Cited by 5

Showing 2 of 5 known citations — external sources report more than can currently be individually listed.

Related research

• Efficacy of Nitrofurantoin and Fosfomycin against Extended Spectrum Beta Lactamase Producing Uropathogens in the Era of Antibiotic Resistance: A Cross-sectional Study — shares topic coverage
• Multidrug-resistant Uropathogens in Urinary Tract Infection Patients: A Comprehensive Study at Al-Rifai Teaching Hospital — shares topic coverage
• Potential of Surface Water Gram-negative Bacterial Flora as a Reservoir of Heterogeneous Plasmid and Multi-drug Resistance Phenomenon — shares topic coverage
• Poultry Environment as a Reservoir of Antimicrobial Resistant Bacteria – A Nigerian Story — shares topic coverage
• Bacteriological Quality and Prevalence of Multidrug Resistant Gram-negative Bacteria from Surface and Underground Domestic Water Sources in Selected Locations in Ibadan, Oyo State, Nigeria — shares topic coverage