Skip to content
Research Article Open access CC BY 4.0

Bioactive Peptides from Marine Molluscs – A Review

Queensley A. Eghianruwa, Omolaja R. Osoniyi, Naomi Maina, Sabina Wachira

International Journal of Biochemistry Research & Review · pp. 1–12 · Published 21 Oct 2019

10.9734/ijbcrr/2019/v27i430130

Abstract

Marine organisms make up approximately half of the total global biodiversity, with the Mollusca containing the second largest number of species, including snails and bivalves. The marine environment is highly competitive, hostile and aggressive, which has led to the production of specific and potent bioactive compounds by the mollusca and their associated microorganisms, in a bid to protect themselves and ensure their survival. A diverse array of bioactive compounds can be isolated from the extracts of marine molluscs of which linear, cyclic, and conjugated peptides and depsipeptides form some of the most important bioactive compounds that have been well characterized and some of have already reached clinical trials or been approved for use as therapeutic agents and supplements. This review highlights some of the bioactive peptides that have been obtained from marine molluscs as well the challenges facing bioprospecting of valuable peptides from marine mollusc sources.

Bioactive peptides novel drug molecules marine mollusks bioprospecting.

References (32)

  1. 1 Peptide therapeutics: current status and future directions [DOI]
  2. 2 Sample size calculation [DOI]
  3. 3 Strategic Approaches to Optimizing Peptide ADME Properties [DOI]
  4. 4 Innate Immunity [DOI]
  5. 5 Bioactive peptides from marine sources: pharmacological properties and isolation procedures [DOI]
  6. 6 Cnidarians as a Source of New Marine Bioactive Compounds—An Overview of the Last Decade and Future Steps for Bioprospecting [DOI]
  7. 7 Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals [DOI]
  8. 8 Original involvement of antimicrobial peptides in mussel innate immunity [DOI]
  9. 9 Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells.
  10. 10 Infectious diseases of marine molluscs and host responses as revealed by genomic tools [DOI]
  11. 11 Synthesis and Structure Determination of Kahalalide F1,2 [DOI]
  12. 12 Actions of intrathecal ω-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat [DOI]
  13. 13 Phase II study of dolastatin-10 in patients with hormone-refractory metastatic prostate adenocarcinoma.
  14. 14 Bioactive Peptide of Marine Origin for the Prevention and Treatment of Non-Communicable Diseases [DOI]
  15. 15 Novel marine-derived anticancer agents: a phase I clinical, pharmacological, and pharmacodynamic study of dolastatin 10 (NSC 376128) in patients with advanced solid tumors.
  16. 16 Managing marine mollusc diseases in the context of regional and international commerce: policy issues and emerging concerns [DOI]
  17. 17 Are the Traditional Medical Uses of Muricidae Molluscs Substantiated by Their Pharmacological Properties and Bioactive Compounds? [DOI]
  18. 18 Phase I Clinical and Pharmacokinetic Study of Kahalalide F Administered Weekly as a 1-Hour Infusion to Patients with Advanced Solid Tumors [DOI]
  19. 19 Amino Acid Composition, Antioxidant, and Cytoprotective Effect of Blue Mussel (Mytilus edulis) Hydrolysate through the Inhibition of Caspase-3 Activation in Oxidative Stress-Mediated Endothelial Cell Injury [DOI]
  20. 20 Bioaccumulation of Hydrocarbon, Heavy Metals and Minerals in Tympanotonus Fuscatus from Coastal Region of Bayelsa State, Nigeria [DOI]
  21. 21 Cardiovascular and autonomic effects of ω‐conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays [DOI]
  22. 22 Bioactive Compounds from Marine Invertebrates for Potential Medicines - An Overview [DOI]
  23. 23 Toxicity of dolastatin 10 in mice, rats and dogs and its clinical relevance [DOI]
  24. 24 Induction of Apoptosis, G0/G1 Phase Arrest and Microtubule Disassembly in K562 Leukemia Cells by Mere15, a Novel Polypeptide from Meretrix meretrix Linnaeus [DOI]
  25. 25 Aktivitas Antioksidan dan Komposisi Kimia Keong Matah Merah (Cerithidea obtusa)
  26. 26 Epifauna diversity and ecology on intertidal flats in the tropical Niger Delta, with remarks on the gastropod speciesHaminoea orbignyana [DOI]
  27. 27 Mere15, a novel polypeptide fromMeretrix meretrix, inhibits adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMPs [DOI]
  28. 28 Two novel peptides derived from Sinonovacula constricta inhibit the proliferation and induce apoptosis of human prostate cancer cells [DOI]
  29. 29 Harvesting Drugs from the Seas and How Taiwan Could Contribute to This Effort
  30. 30 Acute Cardiovascular Toxicity of Low-Dose Intrathecal Ziconotide [DOI]
  31. 31 CONOTOXINS: A POTENTIAL NATURAL THERAPEUTIC FOR PAIN RELIEF
  32. 32 Isolation And Characterization Of Some Kind Bioactive Proteins Sponge As Antibacterial Agent

Cited by 27

Bioactive potential and chemical characterization of Planaxis sulcatus (Phylum: Mollusca, Family: Planaxidae) solvent extracts

Rasha E. M. Ali, Khaled M. Zayed, Ahmed A. Hamed · Advances in Traditional Medicine · 2024

Advancements in nanofabrication of marine biopolymers

Usha Singh, Manisha Bhatia, Manish Kumar · Marine Biopolymers · 2025

Nutraceutical and Medicinal Importance of Marine Molluscs

Yvan Anderson Tchangoue Ngandjui, Tsotlhe Trinity Kereeditse, Ilunga Kamika · Marine Drugs · 2024

Aquatic waste valorization: innovative approaches and sustainable strategies

Sammra Maqsood, Muhammad Tayyab Arshad, Waseem Khalid · Aquatic Waste Valorization · 2026

Lethal and Sub-lethal Implications of Sodium Chloride Exposure for Adult Unionid Mussel Species: Eurynia dilatata and Lasmigona costata

Erika A. Burton, Brian Atkinson, Joseph Salerno · Archives of Environmental Contamination and Toxicology · 2023

A Comprehensive Review on the Valorization of Bioactives from Marine Animal By-Products for Health-Promoting, Biofunctional Cosmetics

Sofia Neonilli A. Papadopoulou, Theodora Adamantidi, Dimitrios Kranas · Marine Drugs · 2025

Showing 9 of 27 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

27

Page views

0

PDF downloads

6

Outbound clicks

27

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.