Effects of Administration of Methanol Root Bark Extract of Cussonia arborea on Serum Biochemical Markers of Kidney Damage and Renal Histomorphology of Alloxan-induced Diabetic Rats

Abstract

Aim: This study evaluated the effects of oral administration of varied doses of methanol root bark extract of Cussonia arborea on some serum biochemical markers of kidney damage and renal histomorphology of alloxan-induced diabetic rats. Methodology: A total of Seventy two (72) male albino wistar rats weighing between 100-105 g were assigned into six groups of 12 rats per group. Groups 1- 5 rats were made diabetic by single intraperitoneal injection of alloxan monohydrate at the dose of 160 mg/kg and treated with 62.5, 125, 250 mg/kg bw of the extracts, 2 mg/kg bw Glibenclamide and 10 ml/kg DW respectively while the non diabetic group 6 rats received 10 ml/kg DW as serve as normal control rats. The treatment was daily through the oral route for 84 days. Serum urea and Creatinine were measured on days 42, 56 and 84 post treatment. At the end of the experiment, the rats were humanly sacrificed and their kidney harvested for histomorphometric assessment. Results: Administration of 125 mg/kg bw of the extract, significantly (p<0.05) reduced the serum levels of urea and creatinine and equally ameliorated histopathologic lesions in the kidney when compared to the diabetic untreated group (negative control). Conclusion: It was concluded that the methanol extract of C. arborea, at the dose of 125 mg/kg was strongly protective against kidney damages occasioned by diabetes