Wound Healing, Evolution of Cancer and War on Cancer

Abstract

This review highlights wound healing, evolution of cancer, and war on cancer. Wound healing requires the proliferation and the terminaldifferentiation (TD) ofprogenitor stem cells (PSCs), which are theprecursors of cancerstem cells (CSCs).Healing wound is not a big deal. If the functionality of chemo-surveillance is intact such as healthy people who can maintain a steady level of wound healing metabolites functioning as differentiation inducers (DIs) and differentiation helper inducers (DHIs).Wounds are always successfully healed without having to put up any effort, just to let the nature to do the healing. Medications such as suture and antibiotics are subsidiary to speed up the healing or to prevent infection. Acute wound affects the functionality of chemo-surveillance only temporarily, which is quickly recovered to return to the normal state. It is the chronic wound such as persistent infectious diseases or exposure to toxic chemicals including carcinogens for a long time that produces damaging effect on the functionality of chemo-surveillance.Chronic wound prompts the production of inflammatory cytokines to cause excessive urinary excretion of wound healing metabolites to affect wound healing. Without sufficient wound healingmetabolites to terminate the proliferation of PCSs, it is very easy for PSCs to evolve into CSCs. It takes only a single hit to silence TET-1 enzyme to complete the transition, which is well within the reach of PSCs equippedwith abnormally active methylation enzymes (MEs).CSCs can then progress to faster growing cancer cells bythe activation of oncogenes or the inactivationof suppressor genes. These are exactly the processes that leadto myelodysplastic syndrome (MDS) and acute myeloidleukemia (AML). Cancer due to wound not healing properly is not unique to MDS and AML. It is rather a common phenomenon.War on cancer can be easily won if the battle is conducted following the nature’s course to heal the wound, just like the success of wound healing without having to put up any effort in healthy people.Therefore, the best strategy to win the war oncancer is to restore the functionality of chemo-surveillanceby the employmentof DIs and DHIs and to preventthe loss of wound healing metabolites through anti-cachexia chemicalssuch as phenylacetylglutamine. Thenthenature will take its course to stop the proliferationof cells with abnormal MEs that include CSCs, PSCs,and all cancer cells. Destruction strategy to kill cancer cells is definitely counter indication. It creates moredamages to the functionalityof chemo-surveillance to stop the growth of cells with abnormal MEs. Inabilityof destruction strategy to putaway CSCsis a decidingfactor to deny the success of destruction strategy to win the war on cancer.