The objective of this article is to promote abnormal methylation enzymes (MEs) as a critical cause of cancer and the destabilization of abnormal MEs as a new approach to direct cancer therapy. MEs are a ternary enzyme complex consisting methionine adenosyltransferase (MAT)-methyl...
Open access
Research Article10.9734/jcti/2025/v15i2295
The objective of this article is to develop cell differentiation agent (CDA) formulations to the rescue of cancer patients whose cancer stem cells (CSCs) have become a dominant issue such as metastatic, unresponsive and recurrent cancer patients. Although CSCs are only a small mi...
Open access
Research Article10.9734/jcti/2024/v14i2254
Cytotoxic chemotherapy was a tragic by-product of World War II. It was the major therapeutic modality employed but failed to win the War on Cancer during 1971-1976 declared by President Nixon. Despite the failure, killing of cancer cells (CCs) remained the commanding principle of...
A right approach is essential to solve any illness. Cancer mortality remains at historic high and is still on the way to increase. The objective of this study is to find a right approach of cancer therapy to bring cancer mortality down. Myelodysplastic syndromes are diseases attr...
Cancer mortality is very high and is still increasing. The objective of this study is to rely on the restoration of chemo-surveillance to reduce cancer mortality called for by President Biden in his cancer moonshot initiative speech last year. The reason cancer mortality remains...
The objective of this study is to present convincing evidence to show that abnormal methylation enzymes (MEs) are the most critical issue of cancer, and to call for the acceptance of cell differentiation agent (CDA) formulations as the right medicines for cancer therapy. CDA form...
Wound healing requires the proliferation and the terminal differentiation of PSCs, the most primitive stem cells expressing abnormal differentiation enzymes (MEs). Wound if not healed properly, PSCs may be forced to evolve into cancer stem cells (CSCs), and then to progress to fa...
It was very sad to learn that President Jimmy Carter and Jane Fonda have given up fights to battle cancer. Terminal stage cancer patients all end up like these two very distinguished figures hopeless to carry on fighting. At terminal stage, patient’s cancer cells (CCs) are loaded...
The objectives of this study were to bring up chemo-surveillance as an important issue to dictate the display of a fatal symptom of pulmonary fibrosis following infection of COVID-19 that can gravely affect cancer patients and to develop CDA formulations for the therapy of pulmon...
Cytotoxic agents were the choice of cancer establishments to combat cancer when President Nixon declared War on Cancer in 1971. After the failure to win the war on cancer during the 5 years of intensive presidential support, it was concluded that cytotoxic agents were unable to w...
Wound healing and cancer evolution are closely related to involve progenitor Stem Cells (PSCs) as the critical common elements. Wound healing requires the proliferation and the Terminal Differentiation (TD) of PSCs. Wound triggers biological and immunological responses. The biolo...
Open access
Research Article10.9734/jcti/2022/v12i130168
This opinion article highlights the mechanism of wound healing and the impact of wound on cancer evolution and cancer therapy. Wound healing requires the proliferation and the terminal differentiation (TD) of progenitor stem cells (PSCs). PSCs are pluripotent stem cells capable o...
This review highlights wound healing, evolution of cancer, and war on cancer. Wound healing requires the proliferation and the terminaldifferentiation (TD) ofprogenitor stem cells (PSCs), which are theprecursors of cancerstem cells (CSCs).Healing wound is not a big deal. If the f...
Cell differentiation agent-2 (CDA-2) was a promising hypomethylating agent approved by the Chinese FDA for the therapy of MDS in China. The active components of CDA-2 are differentiation inducers (DIs) and differentiation helper inducers (DHIs). DIs are chemicals capable of elimi...
Open access
Research Article10.9734/jcti/2020/v10i230125