Assessment of Vino Gano Ginger and Herb Liqueur on the Biochemical Parameters of the Wistar Rats

Abstract

Biochemical parameters are biomarkers used in evaluating the functionality of some bodily organs such as liver, kidneys and the heart. This study aimed at assessing the effects of Vino Gano Ginger And Herbal Liqueur on the Biochemical Parameters of the male Wistar rats. A total of 25 adult male Wistar rats weighing between 115.3 -248.6 g were used for experiment. They were divided into four groups [4 in each group] based on the body weight and different dosage of Vino Gano Ginger and Herb Liqueur were administered to the rats of various groups. Nine [9] out the 24 was used to determine the Sub- acute test to basses toxicity and mortality using Lorke (1983) method. The animals were separated into four [4] groups; control and three treatment groups that received [5 ml/kg, 10 ml/kg and 15 ml/kg] of Vino Gano Ginger and Herb Liquor orally for 4 weeks. The experimental animals were weighed weekly and at the end of the 4th week, they were sacrificed and blood samples were collected for Biochemical Analysis. Results showed significant elevation in mean AST, ALT, ALP, Urea, Creatinine, Total Cholesterol and LDH of the Wistars treated with [5 ml/kg, 10 ml/kg and 15 ml/kg] of the Vino Gano Ginger and Herb Liqueur (p<0.05). A significant Total Protein reduction was recognized of the Wistar rats treated with Vino Gano Ginger and Herb Liqueur. There was slight increase in Albumin in the treatment group 1 [5 ml/kg] but reduction was recorded in treatment groups II and III [10 ml/kg and 15ml/kg]. In conclusion, continues intake of Vino Gano Ginger and Herb Liqueur will pose reno-toxic effect, Myocardial infarction, Cholestasis, Sarcopenia, leukemia and other life treating conditions.