Anti-inflammatory Activity of Herbal Tablet of Phyllanthus emblica on Carrageenan-induced Paw Edema in Wistar Rats
Amulyaratna Behera, Himansu Bhusan Samal, Dinesh Kumar Sharma, Satish Kanhar, Atul Kadam, Prachi Khamkar, Suchismeeta Behera
Journal of Pharmaceutical Research International · pp. 155–167 · Published 11 Dec 2021
10.9734/jpri/2021/v33i54B33776Abstract
Aim: In the current investigation, tablet dosage form of hydroalcohol extract of leaves of P. emblica was developed and evaluated foranti-inflammatory activities. Methodology: Hydroalcohol extract of leaves of P. Emblica (HPE) was prepared and formulated tablet dosage form. The mechanical properties e.g. hardness, friability, disintegration, and dissolution of tablet were evaluated. Anti-inflammatory activities of HPE (150 mg/kg) and HPE (650 mg) tablets were performed in carrageenan induced hind paw edema in wistar rats. Results: The anti-inflammatory activity was found to be significant in carrageenan inducedpaw edema. HPE (150 mg/kg) and HPE tablets (650 mg) were significantly (p < 0.05) reduced the carrageenan induced paw edemaby 66.41% and 69.43% respectively as compared to carragenan control. The % inhibition of standard drug (dichlorofenac sodium) was recorded to be 70.18% after 5 h. Conclusion: The study standardised the development of HPE tablet and its anti-inflammatory effect.
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