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Research Article Open access CC BY 4.0

Application of Mathematical Models in Drug Release Kinetics of Cyanocobalamine Fast Dissolving Sublingual Film

Adil Patel, Ami Kalsariya, Srushti Patel, Chandni Patel, Shreya Patel

Asian Journal of Medicine and Health · pp. 72–81 · Published 13 Aug 2021

10.9734/ajmah/2021/v19i830360

Abstract

The aim of present work is to determine and analyse the kinetics of drug release from the fast dissolving sublingual by employing various mathematical models. A study was done with Cyanocobalamine fast dissolving sublingual films, 1.5 mg/film by employing solvent casting technique using dehydrated banana starch and Gelatin. The in-vitro drug release profile was carried out in pH 6.8 phosphate buffer (900 mL) using USP dissolution apparatus I (Basket) at 50 rpm for 20 mins. The drug release data was obtained, quantitatively correlated and interpreted with various mathematical models viz. Zero order model, first order model, Higuchi model, Hixson-Crowell model and Korsmeyer-Peppas model and evaluated to understand the kinetics of drug release. The criterion for the most suitable model was based on the high degree of coefficient of correlation of drug release profile of Cyanocobalamine fast dissolving sublingual films.

Dissolution diffusion coefficient of correlation kinetics of drug release

References (4)

  1. 1 Kinetic modeling on drug release from controlled drug delivery systems.
  2. 2 Goodness-of-Fit Model-Dependent Approach for Release Kinetics of Levofloxacin Hemihydrates Floating Tablet [DOI]
  3. 3 DESIGN AND EVALUATION OF DRUG RELEASE KINETICS OF MELOXICAM SUSTAINED RELEASE MATRIX TABLETS
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