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Research Article Open access CC BY 4.0

An Overview of COVID-19 Vaccines: Challenges of the Discovery and Development by the Pharmaceutical Industries

Estella Achick Tembe-Fokunang, Andrew Nyuyki Banin, Joseph Fokam, Dobgima John Fonmboh, Kristen Nubia Kaba, Lovet Benyella Fokunang, Ben Enoluomen Ehigiator, Zelinjo N. Igweze, Sarah Tishkoff, Ralf Duerr, Charles Ntungwen Fokunang

International Journal of Pathogen Research · pp. 13–31 · Published 9 Nov 2022

10.9734/ijpr/2022/v11i2209

Abstract

The coronavirus (COVID-19) took the world by storm and triggered intensive research mobilization and action towards vaccines and drug repurposing. This pandemic triggered an emergence therapy intervention of which the development of new vaccine and drug repurposing were good options that was to be validated by regulatory authorities for potential use for enhancing acquired immunity for the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Prior to the outbreak that led to the global health emergency intervention, an understanding of the viral architecture, pathophysiology and mechanism of action and functions were well established.  The global health disaster caused by COVID-19 has generated significant interest globally for research in vaccine discovery and development by many research institutions and Pharmaceutical sectors since 2019. So far, the approval of many clinical trials tested vaccines by the regulatory authorities have led to the need for post approval concerns of efficacy, safety and quality of these approved vaccines. This review paper attempts to explore the vaccines approved for global access to the population discovery and development process, the potential safety implications. An insight into other therapy options such as the convalescence plasma treatment and management for the global COVID-19 pandemic has been reviewed.

Coronavirus COVID-19 vaccine SARS-COV-2 immunity China

References (58)

  1. 1 Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [DOI]
  2. 2 Determinants of disparities between perceived and physiological risk of falling among elderly people: cohort study. [DOI]
  3. 3 Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) [DOI]
  4. 4 Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination [DOI]
  5. 5 Vaccine hesitancy [DOI]
  6. 6 The COVID-19 vaccine development landscape [DOI]
  7. 7 Covid-19 — Navigating the Uncharted [DOI]
  8. 8 Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials [DOI]
  9. 9 Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial [DOI]
  10. 10 Responding to Covid-19 — A Once-in-a-Century Pandemic? [DOI]
  11. 11 Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery [DOI]
  12. 12 What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2 [DOI]
  13. 13 β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway [DOI]
  14. 14 Evolution of the COVID-19 vaccine development landscape [DOI]
  15. 15 Convalescent plasma in Covid-19: Possible mechanisms of action [DOI]
  16. 16 Coronavirus vaccine development: from SARS and MERS to COVID-19 [DOI]
  17. 17 BNT162b2 mRNA COVID-19 Vaccine: First Approval [DOI]
  18. 18 Autoimmune heparin‐induced thrombocytopenia [DOI]
  19. 19 Sputnik V COVID-19 vaccine candidate appears safe and effective [DOI]
  20. 20 Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review [DOI]
  21. 21 Three decades of messenger RNA vaccine development [DOI]
  22. 22 COVID-19 in Children: Where do we Stand? [DOI]
  23. 23 Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus [DOI]
  24. 24 Non-viral COVID-19 vaccine delivery systems [DOI]
  25. 25 Disease X: accelerating the development of medical countermeasures for the next pandemic [DOI]
  26. 26 Reserving coronavirus disease 2019 vaccines for global access: cross sectional analysis [DOI]
  27. 27 COVID‐19 vaccine‐associated immune thrombosis and thrombocytopenia (VITT): Diagnostic and therapeutic recommendations for a new syndrome [DOI]
  28. 28 Coronavirus Disease (COVID-19): Current Status and Prospects for Drug and Vaccine Development [DOI]
  29. 29 Development and Characterization of a Severe Acute Respiratory Syndrome–Associated Coronavirus–Neutralizing Human Monoclonal Antibody That Provides Effective Immunoprophylaxis in Mice [DOI]
  30. 30 COVID-19 vaccine: where are we now and where should we go? [DOI]
  31. 31 Splanchnic Vein Thrombosis: Current Perspectives [DOI]
  32. 32 COVID‐19 vaccine research and development: ethical issues [DOI]
  33. 33 COVID-19 vaccine development: a pediatric perspective [DOI]
  34. 34 Cutaneous Adverse Reactions to COVID-19 Vaccines: Insights from an Immuno-Dermatological Perspective [DOI]
  35. 35 Therapy with a Severe Acute Respiratory Syndrome–Associated Coronavirus–Neutralizing Human Monoclonal Antibody Reduces Disease Severity and Viral Burden in Golden Syrian Hamsters [DOI]
  36. 36 COVID-19 Vaccine and Myocarditis [DOI]
  37. 37 The coronavirus disease (COVID-19) – A supportive approach with selected micronutrients [DOI]
  38. 38 SARS (Severe Acute Respiratory Syndrome)
  39. 39 Convalescent plasma for covid-19 [DOI]
  40. 40 Severe acute respiratory syndrome [DOI]
  41. 41 Middle East respiratory syndrome coronavirus: a comprehensive review [DOI]
  42. 42 J&J’s one-shot COVID vaccine offers hope for faster protection [DOI]
  43. 43 COVID-19 vaccine dilemmas [DOI]
  44. 44 The Drug Development Process [DOI]
  45. 45 Convalescent plasma treatment for COVID‐19: Tempering expectations with the influenza experience [DOI]
  46. 46 Underpromise, overdeliver [DOI]
  47. 47 COVID-19 Vaccines as Global Common Goods: An Integrated Approach of Ethical, Economic Policy and Intellectual Property Management [DOI]
  48. 48 Science [DOI]
  49. 49 How COVID vaccines are being divvied up around the world [DOI]
  50. 50 Convalescent plasma is ineffective for covid-19 [DOI]
  51. 51 Real-world effectiveness of COVID-19 vaccines: a literature review and meta-analysis [DOI]
  52. 52 Association Between 3 Doses of mRNA COVID-19 Vaccine and Symptomatic Infection Caused by the SARS-CoV-2 Omicron and Delta Variants [DOI]
  53. 53 New‐onset autoimmune phenomena post‐COVID‐19 vaccination [DOI]
  54. 54 Diagnostics for COVID-19: moving from pandemic response to control [DOI]
  55. 55 Covid-19: Omicron may be more transmissible than other variants and partly resistant to existing vaccines, scientists fear [DOI]
  56. 56 Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review [DOI]
  57. 57 Systematic review of the safety, immunogenicity, and effectiveness of COVID‐19 vaccines in pregnant and lactating individuals and their infants [DOI]
  58. 58 Antidoping Concept of Play Clean to Win Clean: Implication of Herbal Supplements uses for Athletes in Competitive Sports [DOI]

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