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Charles Ntungwen Fokunang

Publications (18)

Artificial Intelligence in Medical Research: Ethical and Regulatory Challenges in Developing Economies

Charles Ntungwen Fokunang, Marceline Djuidje Ngounoue, Joseph Fokam, Estella Achick Tembe-Fokunang, Basile Ngono, Innocente Mantsana, Mfochive Njindam Illiasou, Christie Tiwoda, Francis Ndongo Ateba, Tchinda Tiabou, Lowe Gnintedem Patrick Juvet, Pasteur Sap Jacques Duclaire, Mgr Etoundi Jean, Mpah Wanga Julien Eymard, Ngu Paul Nembo, Jerome Ateudjio, Charles Kouanfack, Eboumbou Moukoko Caroline Else, Leopold Lehman, Binan Fidele Ange, Lovet Benyella Fokunang, Atanga Benjamin, Zoung-Khanyi Bisseck Anne Cécile, Marie Claire Assoumou Okomo, Dickson Shey Nsagha, Mbacham Fon Wilfred, Marie Therese Obama Abena Ondoua, Zintchem Roger & Vincent Pryde Kehdingha Titanji · Journal of Advances in Medical and Pharmaceutical Sciences · 2025

Introduction: Clinical research is a key area in which the use of AI in healthcare data seen a significant increase, even though met with great ethical, legal and regulatory challenges. Artificial Intelligence (AI) concerns the ability of algorithms encoded in technology to learn...

Open access Research Article 10.9734/jamps/2025/v27i6788

Ethical and Regulatory Challenges for Contract Research Organizations Conducting (Outsourced) Clinical Research in Sub-Saharan Africa with a Case Study of Cameroon

Charles Ntungwen Fokunang, Estella Achick Tembe-Fokunang, Marceline Djuidje Ngounou, Basile Ngono, Innocente Mantsana, Pasteur Sap Jacques Duclaire, Mgr Etoundi Jean, Mpah Wanga Julien Eymard, Mfochive Njindam Illiasou, Christie Tiwoda, Francis Ndongo Ateba, Tchinda Tiabou, Lowe Gnintedem Patrick, Eboumbou Moukoko Caroline Else, Ngu Paul Nembo, Jerome Ateudjio, Charles Kouanfack, Leopold Lehman, Binan Fidele Ange, Marie Claire Assoumou Okomo, Mbacham Fon Wilfred & Vincent Pryde Kehdingha Titanji · Journal of Advances in Medical and Pharmaceutical Sciences · 2025

Introduction: Contract Research Organizations (CROs), Clinical Research Centers/Networks and private research institutions play an important role in the clinical research process, especially in the drug discovery and development process. They act as essential partners for pharmac...

Open access Research Article 10.9734/jamps/2025/v27i4768

Overview of the Advancement in the Drug Discovery and Contribution in the Drug Development Process

Estella Tembe Fokunang & Charles Ntungwen Fokunang · Journal of Advances in Medical and Pharmaceutical Sciences · 2022

The drug discovery and development of a new chemical entity from original idea to the regulatory approval for launch into the market is a very long and complex journey. The process is complex and can take between 10-15 years, with a significant financial implication of cost of ab...

Open access Research Article 10.9734/jamps/2022/v24i10580

Assessment of Medication Therapy Management in Patients on Haemodialysis at the Yaoundé University Teaching Hospital, Cameroon

Simone Félicia NGO WASNYO, Estella Achick Tembe Fokunang, Francoise Kaze FOLEFACK & Charles Ntungwen Fokunang · International Journal of Advances in Nephrology Research · 2026

Introduction: Clinical pharmacy is a branch of pharmacy that is patient centred. It was born in the Western world and is well established in countries like USA, Canada, United Kingdom and France. In Cameroon, it was recently (2022) introduced in the medical training programme as...

Open access Research Article 10.9734/ijanr/2026/v9i190

Knowledge, Attitudes and Practices on Exposure to Camphor & Eucalyptus Essential Oils and Risk of Seizure Disorder in Children: A Cross Sectional Study

Marie Victoria Eyog Nkolo, Mbassi, Awah Hubert Desire, Estella Tembe Fokunang & Charles Ntungwen Fokunang · Journal of Complementary and Alternative Medical Research · 2024

Background: Camphor and eucalyptus essential oils contain camphor and eucalyptol respectively which serve as active ingredients in over-the-counter drugs to manage upper respiratory tract infections and pain in children.  However, because of their pro-convulsant properties, seizu...

Open access Research Article 10.9734/jocamr/2024/v25i2519

Evaluation of the Therapeutic Approach and Outcome of Type 2 Diabetes Mellitus Management Strategies in Cameroon

Lukong Marie Chantal Suinyuy, Tembe Estella Fokunang, Dehayen Mesmin, Ngo Valery Ngo & Charles Ntungwen Fokunang · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Introduction: Type 2 diabetes mellitus (T2DM) is a metabolic syndrome that is characterized by chronic hyperglycaemia, and can lead to chronic long-term complications. The prevalence of diabetes mellitus in Cameroon has been reported at 5.9% in 2017. Studies conducted in 2011, sh...

Open access Research Article 10.9734/jamps/2019/v20i430115

Phytochemical Characterisation and Antibacterial Activity of Propolis on Cariogenic Microrganisms

Ashu Michael Agbor, Raissa Tsague, Bruno Kaptue, Sudeshni Naidoo, Estella Tembe-Fokunang, Charles Ntungwen Fokunang & Charles Pilipili · European Journal of Medicinal Plants · 2020

Background: Dental caries is also known as tooth decay is as a result of the softening of hard dental tissues from factors of multiple origins, with dental plaque bacteria being one of the most important factors. Due to the resistance of microorganisms to common antibiotics, mode...

Open access Research Article 10.9734/ejmp/2020/v31i430232

Evaluation of the Antimicrobial Potentials and Adverse Effect of Kolanut (Kola nitida Malvaceae) on the Oral Cavity and the Impact on Cariogenic Bacteria: A Socio-Demographic Study

Ashu Michael Agbor, Marie Ebob Agbor-Tabot Bissong, Estella Tembe-Fokunang, Clinton Eyong, Kaba KOUROUMA & Charles Ntungwen Fokunang · Journal of Advances in Medical and Pharmaceutical Sciences · 2019

Kola nut (Kola nitida, Malvaceae) is one of the nuts consumed for socio-cultural reasons in West Africa sub-region and it has been used in Western African and Anglo-American herbal medicine as an antidepressant. The aim of this study was to evaluate the beneficial and adverse eff...

Open access Research Article 10.9734/jamps/2019/v20i130102

An Overview of Pharmacovigilance and Adverse Drug Reaction Monitoring of Drugs and Vaccines during the COVID-19 Pandemic

Estella Achick Tembe-Fokunang, Banin Andrew Nyuki, Joseph Fokam, Dobgima John Fonmboh, Kristen Nubia Kaba, Lovet Benyella Fokunang, François-Xavier Mbopi-Keou, Abena, Ondoua Obama Marie Therese, Ralf Duerr & Charles Ntungwen Fokunang · Journal of Advances in Medical and Pharmaceutical Sciences · 2022

Once a drug is approved in phase III of clinical trials, pharmacovigilance (PV) becomes very important for the surveillance of drug, vaccine or medical devices. PV constitutes part of the phase IV approval, which involves a study for collecting, detecting, and monitoring adverse...

Open access Research Article 10.9734/jamps/2022/v24i630308

Antidoping Concept of Play Clean to Win Clean: Implication of Herbal Supplements uses for Athletes in Competitive Sports

John Dobgima Fonmboh, Estella Achick Tembe Fokunang, Ngono Mballa Rose, Tama Wango, Richard Aba Ejoh, Nubia Christian Kaba, Michel Disake, Jeane Yonkeu Ngogang, Robert Ndjana & Charles Ntungwen Fokunang · Journal of Advances in Medicine and Medical Research · 2021

The popularity of doping in competitive sports is relevant for all those involved in sports, particularly for evaluating anti-doping policy measures. However, there is a gap of information that addresses this subject so far. As a consequence, the prevalence of doping in competiti...

Open access Research Article 10.9734/jammr/2021/v33i2231158

An Overview of the Ethnobotanic, Ethnopharmacological and Medicinal Importance of Edible Wild Root Tuber Orchids in Cameroon

Dobgima John Fonmboh, Tembe Estella Fokunang, Ngwasiri Pride Ndasi, Noumo Thierry Ngangmou, Bayaga Herve, Bengyella Louis Tita, Kaba Christian Nubia, Tita Margaret Awah, Ejoh Richard Aba & Charles Ntungwen Fokunang · Asian Journal of Biotechnology and Bioresource Technology · 2021

Orchids are well known for their beautiful exotic flowers, and food-flavoring products which make them a resource of great economic importance in the global horticultural and food industries. In Cameroon, orchids are particularly important for their tubers which are used for food...

Open access Research Article 10.9734/ajb2t/2021/v7i430106

Pharmacovigilance in Cameroon: Past, Present and Future Developments in Unlocking the Drug Development Process

Estella Achick Tembe Fokunang, Bruna Njeba, Marie Jose Essi, Rose Ngono Abondo, Banin Andrew Nyuki, Lovet Benyella Fokunang, Nubia Kaba, Marie-Thérèse Abena Ondoua, Ralf Duerr & Charles Ntungwen Fokunang · Journal of Advances in Medical and Pharmaceutical Sciences · 2020

The drug discovery and development processes are designed to guarantee that drugs are efficacious, nontoxic and of high standards of quality for human consumption. However, patient’s population with access to drugs at approval is only a fraction of the final target population. Th...

Open access Research Article 10.9734/jamps/2020/v22i930192

Preclinical Evaluation of the Anti-inflammatory Properties of Plants Extracts of Ficus exasperata (Moraceae) on Wistar Rat Models

Bate Antuan Asue, Edith Lem Abongwa, Vanessa Tchadji Mayoudom, Bayaga Herve Narcisse, Ndikum Valentine, Lovet Benyella Fokunang, Njinkio Nono Borgia, Estella Tembe-Fokunang, Bathelemy Ngameni, Sameh Abouzid & Charles Ntungwen Fokunang · Journal of Advances in Medical and Pharmaceutical Sciences · 2025

Introduction: In view of the rising global death rate associated with inflammatory diseases, a cost friendly, more effective and, safer drug with lesser side effects is needed.  Inflammation is a part of the complex biological response of vascular tissue to harmful stimuli, such...

Open access Research Article 10.9734/jamps/2025/v27i1746

An Overview of COVID-19 Vaccines: Challenges of the Discovery and Development by the Pharmaceutical Industries

Estella Achick Tembe-Fokunang, Andrew Nyuyki Banin, Joseph Fokam, Dobgima John Fonmboh, Kristen Nubia Kaba, Lovet Benyella Fokunang, Ben Enoluomen Ehigiator, Zelinjo N. Igweze, Sarah Tishkoff, Ralf Duerr & Charles Ntungwen Fokunang · International Journal of Pathogen Research · 2022

The coronavirus (COVID-19) took the world by storm and triggered intensive research mobilization and action towards vaccines and drug repurposing. This pandemic triggered an emergence therapy intervention of which the development of new vaccine and drug repurposing were good opti...

Open access Research Article 10.9734/ijpr/2022/v11i2209

Pharmacovigilance of Natural Herbal Medicines Research for Efficacy, Safety and Quality Assurance of Phytomedicine Products

Estella Tembe Fokunang, Dobgima John Fonmboh, Rose Ngono Mballa, Andrew Banin Nyuyki, Lovet Benyella Fokunang, Nubia Kaba, Thérèse Bwemba Abong, Ralf Duerr, Ejoh Richard, Marie-Thérèse Abena Ondoua & Charles Ntungwen Fokunang · Journal of Complementary and Alternative Medical Research · 2020

Improved traditional medicine/phytomedicine formulations have gained a global acceptability and popularity as therapeutic agents for many diseases in Sub-Saharan Africa. Herbal products are generally considered as safe, environmentally friendly and increasingly consumed by the co...

Open access Research Article 10.9734/jocamr/2020/v12i130198

Phytochemical Analysis of Bioactive Compounds of the Leaf Extracts of Ficus exasperata Vahl. (Moraceae)

Bate Antuan Asue, Lem Edith Abongwa, Mbong Grace Annih, Bayaga Herve Narcisse, Vanessa Tchadji Mayoudom, Dobgima John Fomnboh, Lovet Benyella Fokunang, Njinkio Nono Borgia, Estella Tembe-Fokunang, Bathelemy Ngameni, Charles Esimone & Charles Ntungwen Fokunang · Journal of Complementary and Alternative Medical Research · 2025

Introduction: Ficus exasperata Vahl. (Moraceae) is a perennial herb with a long history of traditional medicinal use in the tropical and subtropical regions of the world. The present study was designed to screen the major groups of phytochemicals found in the leaf parts of the pl...

Open access Research Article 10.9734/jocamr/2025/v26i5651

The Scope of Aplastic Anaemia: Etiology, Pathophysiology, Pharmacotherapy and Pharmacoeconomic Impact in Clinical Patient Management

Estella Tembe-Fokunang, Marceline Djuidje Nganoue, Vanessa Edwige Tchadji Mayoudom, Frederick Kechia Aghem, Ngo Sack Françoise, Toukam Michel, Tayou Tagny Claude, Ngum Samuel, Marie Jose Essi, Dora Mbanya, Marie Therese Abena Obama Ondoua & Charles Ntungwen Fokunang · International Journal of Research and Reports in Hematology · 2022

The blood disease called aplastic anaemia (AA) isconsidered a rare blood condition known to be in some occasion to be a public health concern, as a life-threatening health accounting for the major causes of bone marrow failure. AA may provoke bone marrow hypoplasia or aplasia in...

Open access Research Article

Forensic Toxicology Concepts and Applications in Pharmaceutical Medicine

Tembe Estella Fokunang, Tchadji Mayoudom Vanessa Edwige, Mbong Annih Grace, Pipiponsuhu Isaac, Daniel Okpuno, Eseoghenemena Ubuara, Obiakor Conscience, Ben Enoluomen Ehigiator, Zelinjo N Igweze, Zintchem Roger, Ngo Valery Ngo & Charles Ntungwen Fokunang · Asian Journal of Medical Principles and Clinical Practice · 2022

Forensic toxicology is a branch of toxicology which aligns with other disciplines such as analytical chemistry, pharmacology, clinical chemistry, contributing to medico-legal investigations of adverse effects like death, poisoning and drug abuse. The focus of forensic toxicology...

Open access Research Article