An Efficient Synthesis of Anti-spasmodic Drug Mebeverine Hydrochloride
V. S. R. N. Phanikumar, G. Veera Raghava Sharma
Journal of Pharmaceutical Research International · pp. 325–331 · Published 14 Dec 2021
10.9734/jpri/2021/v33i57B34063Abstract
An efficient synthetic process for an antispasmodic drug and active pharmaceutical ingredient of Mebeverine hydrochloride 1 is reported in this communication. It is used for stomach cramps and irritable bowel syndrome (IBS). The treatment for irritable bowel syndrome involves lot of drugs like (Dicyclomine hydrochloride, Linaclotide.etc) available in market, but Mebeverine hydrochloride (1) is most effective than any other drug. Earlier manufacturing 1 process reported yield < 46% and used high volumes of reagents and expensive catalyst. We developed new commercial process for 1 with economically, environmentally favored conditions. Proposed synthetic route contains three stages with overall yield of 77% and Purity by HPLC NLT 99.7%.
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