Skip to content
Research Article Open access CC BY 4.0

Ameliorative Effect of Aqueous Crude Extract of the Aerial Parts of Leonurus Cardiaca on Doxorubicin-Induced Cardiovascular Damage in Wistar Rats

E. O. Wellington, M. B. Otobo, S. J. Ogbomade

International Journal of Biochemistry Research & Review · pp. 22–36 · Published 17 Aug 2023

10.9734/ijbcrr/2023/v32i6820

Abstract

This study investigated the ameliorative effect of aqueous crude extract of the aerial parts of Leonurus cardiaca on doxorubicin-induced cardiovascular damage in Wistar rats. Aqueous crude extract of Leonurus cardiaca was prepared based on standard Laboratory condition. A total of 55 male and female rats weighing between 170 ± 15 and 180±15g were used for this study. The rats were grouped into 11 groups of five rats per group. Group 1 and 2 served as normal and negative control rats respectively. Rats in group 3-11 were intraperitoneally administered 18mg/kg of doxorubicin once and were treated with the crude extract  at 166, 250, and 500mg/kg for 7, 14, and 21 days.  All biochemical, hematological, and histological analyses were carried out based on standard methods. The mean plasma troponin T and I, IL-6 and C-reactive protein concentrations of the negative control were 357.93±0.01 pg/mL, 241.51±0.00  pg/mL, 63.94±0.01 pg/dl, and 41.03±0.01 mg/ml respectively. The plasma troponin T and I, IL-6 and C-reactive protein concentrations treated for 21 days were 270.32±0.01 pg/mL, 217.84±0.01 pg/mL, 42.75±0.01 pg/dl, and 18.03±0.01 mg/ml respectively. The mean MDA, GSH concentrations, GPx, CAT and SOD activities in doxorubicin-induced cardiovascular damage rats, treated with the extract at  500mg/kg were 5.01±0.01mmol/l, 68.46±0.02µg/mg.protein, 70.21±0.01mg/pro.min, 141.62±1.80IU/g, and 19.05±0.02mg/g  respectively and were significantly different from those of group 2. Aqueous crude extract of Leonurus cardiaca at 500mg/kg ameliorated the damage induced by doxorubicin on the heart tissues, hence could serve as a novel herbal agent for the treatment of cardiovascular damage.

Cardiovascular damage doxorubicin heart tissue Leonurus cardiac oxidative stress and Wistar rats

References (25)

  1. 1 Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple [DOI]
  2. 2 Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies [DOI]
  3. 3 Doxorubicin induced heart failure: Phenotype and molecular mechanisms [DOI]
  4. 4 Cardioprotective mechanisms of phytochemicals against doxorubicin-induced cardiotoxicity [DOI]
  5. 5 GENERAL AND APPLIED PLANT PHYSIOLOGY
  6. 6 Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis [DOI]
  7. 7 Oxidative stress tests: overview on reliability and use
  8. 8 Troponin: structure, properties, and mechanism of functioning.
  9. 9 Ameliorative effects of N-acetylcysteine on fluoride-induced oxidative stress and DNA damage in male rats’ testis [DOI]
  10. 10 The Liver and Kidneys mediate clearance of cardiac troponin in the rat [DOI]
  11. 11 Cardioprotective Effect of Selenium Against Cyclophosphamide-Induced Cardiotoxicity in Rats [DOI]
  12. 12 Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus [DOI]
  13. 13 Cardioprotective properties of Artemisia herba alba nanoparticles against heart attack in rats: A study of the antioxidant and hypolipidemic activities [DOI]
  14. 14 Pharmacological effects of lavandulifolioside from Leonurus cardiaca [DOI]
  15. 15 GABAA Receptor Binding Assays of Standardized Leonurus cardiaca and Leonurus japonicus Extracts as Well as Their Isolated Constituents [DOI]
  16. 16 Cardioprotective Effect of Crude Extract and Solvent Fractions of Urtica simensis Leaves on Cyclophosphamide-Induced Myocardial Injury in Rats [DOI]
  17. 17 Lemon Juice Elevated Level of Reduced Glutathione and Improved Lipid Profile in Wistar Rats
  18. 18 [Lycopene's protective effect on oxidative damage of L02 cells and its mechanism].
  19. 19 Acute, Sub-acute and Chronic Toxicity Evaluation of Aqueous Extract of the Aerial Parts of Leonurus cardiaca in Normal Non-pregnant Female Wistar Albino Rats per OECD 425 TG [DOI]
  20. 20 Phytochemical and Essential Oil Characterization of the Aerial Parts of Leonurus cardiaca (Motherworth) [DOI]
  21. 21 MIcroProPAGAtIon oF LEONURUS CARDIACA - InFLuEncE oF AuXInS And cYtoKInInS
  22. 22 Effect of Saccharum barberi extract on lipid profile level in albino wistar rats
  23. 23 Effect of Aqueous Extract of the Aerial Parts of Leonurus cardiaca On Cisplatin-induced Hepato-renal Damage in Wistar Albino Rats [DOI]
  24. 24 Journal of Applied Life Sciences International [DOI]
  25. 25 Asian Journal of Food Research and Nutrition [DOI]

Cited by 2

Medicinal Plants and Phytochemicals in Cardioprotection—Mechanistic Pathways and Translational Roadmap

Diana Maria Morariu-Briciu, Alex-Robert Jîjie, S. Bolintineanu · Life · 2026

Showing 1 of 2 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

26

Page views

0

PDF downloads

3

Outbound clicks

2

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.