African Natural Products with Potential Anti-trypanosomal Properties: A Review
L. Bashir, O. K. Shittu, S. Sani, M. B. Busari, K. A. Adeniyi
International Journal of Biochemistry Research & Review · pp. 45–79 · Published 13 Apr 2015
10.9734/IJBCRR/2015/16039Abstract
African Natural Products with Potential Anti-trypanosomal Properties: A Review Ethnopharmacological Relevance: Africa is considered to be the cradle of mankind with a rich biological and cultural diversity marked regional difference in healing practices. Natural product of Africa represents a constant interest as sources of health remedies, nutrition and cosmetic formulations. African trypanosomiasis is one of the neglected tropical diseases caused by fly-borne protozoa known as trypanosomes that affect both human and livestock with devastating consequences. Chemotherapy of African trypanosomiasis is unsatisfactory for various reasons including unacceptable toxicity, poor efficacy, undesirable route of administration and drug resistance. In this regards, the last few decades have witnessed a surfeit of investigations which have been geared to investigate the effect of common traditionally-used medicinal plants/insect in alleviating the cellular changes produced during trypanosome infection. Major Objective: This review presents the profiles of African natural product (plants and insect) with anti-trypanosomal properties, reported in the literature. Methodology: Literature was collected from published articles (through electronic search), thesis, Proceedings as well as book of abstract that report on the in vitro or in vivo anti-trypanosomal activity of plants, insects and their products. Results: A total of 215 plants pecies from 82 families were found. While two herbal formulation and three insect/there product were reviewed for invivo anti-trypanosomal activity Furthermore, some of the plants were investigated for possible ameliorative effects on the trypanosome-induced pathological changes. Phyto- chemistry studies of the anti-trypanosomal plants led to the isolation of 96 specific bioactive anti-trypanosomal compounds from different parts of the plants Conclusion: It is clear that these reviews provide strong evidence of the potential beneficial effects of phytotherapy in the traditional management of trypanosomiasis, which could be subsequently developed into a cost effective alternative medicine to complement treatment of trypanosomiasis.
References (53)
- 1 Medicinal plants: Traditions of yesterday and drugs of tomorrow [DOI]
- 2 A review of Piper spp. (Piperaceae) phytochemistry, insecticidal activity and mode of action [DOI]
- 3 The development of drugs for treatment of sleeping sickness: a historical review [DOI]
- 4 Volatile components of four Ethiopian Artemisia species extracts and their in vitro antitrypanosomal and cytotoxic activities [DOI]
- 5 New Culture Medium for Maintenance of Tsetse Tissues and Growth of Trypanosomatids* [DOI]
- 6 In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo [DOI]
- 7 In vitro antitrypanosomal activity of ethnopharmacologically selected Beninese plants [DOI]
- 8 The antiprotozoal activity of methylated flavonoids from Ageratum conyzoides L. [DOI]
- 9 Ethno-veterinary medicine: screening of Nigerian medicinal plants for trypanocidal properties [DOI]
- 10 Anti-trypanosomal activity of African medicinal plants: A review update [DOI]
- 11 Trypanocidal and Leishmanicidal Activities of Flavonoids from Argentine Medicinal Plants [DOI]
- 12 Screening of some Tanzanian medicinal plants for their trypanocidal and cytotoxic activities [DOI]
- 13 In vitro antitrypanosomal and antiplasmodial activities of crude extracts and essential oils of Ocimum gratissimum Linn from Benin and influence of vegetative stage [DOI]
- 14 Vernoguinosterol and vernoguinoside, trypanocidal stigmastane derivatives from Vernonia guineensis (Asteraceae) [DOI]
- 15 Antiprotozoal Screening of 60 South African Plants, and the Identification of the Antitrypanosomal Germacranolides Schkuhrin I and II [DOI]
- 16 In vitro anti trypanosomal activity of some medicinal plants used in the treatment of trypanosomosis in Northern Nigeria [DOI]
- 17 Novel antitrypanosomal agents [DOI]
- 18 Antitrypanosomal effects of petroleum ether, chloroform and methanol extracts of Artemisia maciverae Linn.
- 19 In vitro antitrypanosomal activity of African plants used in traditional medicine in Uganda to treat sleeping sickness [DOI]
- 20 Antitrypanosomal activity of some medicinal plants from Nigerian ethnomedicine [DOI]
- 21 In vitro and in vivo trypanocidal effect of lipophilic extracts of medicinal plants from Mali and Burkina Faso [DOI]
- 22 In vitro antileishmanial and antitrypanosomal activities of five medicinal plants from Burkina Faso [DOI]
- 23 Antitrypanosomal isoflavan quinones from Abrus precatorius [DOI]
- 24 In vitro antitrypanosomal activity of aqueous and methanolic crude extracts of stem bark of Ximenia americana on Trypanosoma congolense [DOI]
- 25 Antiprotozoal activity and cytotoxicity of metabolites from leaves of Teclea trichocarpa [DOI]
- 26 Antitrypanosomal and cytotoxic activities of pyrrolizidine alkaloid-producing plants of Ethiopia [DOI]
- 27 Trypanocidal activity of flavonoids and limonoids isolated from Myrsinaceae and Meliaceae active plant extracts [DOI]
- 28 Anti–trypanosomal effect of Peristrophe bicalyculata extract on Trypanosoma brucei brucei–infected rats [DOI]
- 29 New Insights in Staging and Chemotherapy of African Trypanosomiasis and Possible Contribution of Medicinal Plants [DOI]
- 30 Phytochemical Screening and In Vitro Antitrypanosomal Activity of Aqueous and Methanol Leaf Extract of Verbascum sinaiticum (Scrophulariaceae) against Trypanosoma congolense Field Isolate [DOI]
- 31 In vitro and in vivo animal model antitrypanosomal evaluation of ten medicinal plant extracts from south west Nigeria [DOI]
- 32 Antiplasmodial and Antitrypanosomal Activity of Pyrethrins and Pyrethroids [DOI]
- 33 Genetic epidemiology of trypanosoma cruzi infection and Chagas disease [DOI]
- 34 Evaluation of Medicinal Plants from Nupeland for Their in vivo Antitrypanosomal Activity [DOI]
- 35 In vitro anti trypanosomal activity of crude extracts of some Nigerian medicinal plants.
- 36 Efficacy of Dissotis rotundifolia on Trypanosoma brucei brucei infection in rats [DOI]
- 37 Saponins-rich fraction of Calotropis procera leaves elicit no antitrypanosomal activity in a rat model [DOI]
- 38 Scientific Investigation of Antitrypanosomal Activity of Crateva Adansonii DC Leaves Extracts [DOI]
- 39 In vitro anti-trypanosomal activity of Morinda lucida leaves [DOI]
- 40 Studies on the In Vitro Trypanocidal Effect of the Extracts of Some Selected Medicinal Plants in Sokoto State, Nigeria [DOI]
- 41 Evaluation of trypanosomal activity of Tapinanthus globiferus and Gongronema latifolium on Trypanosoma congolense
- 42 In vitro and in vivo Antitrypanosomal Effects of Methanol and Aqueous Extracts of Picralima nitida [DOI]
- 43 In vitro Antiplasmodial, Antitrypanosomal, Antileishmanial and Cytotoxic Activities of Various Fractions of Abrus precatorius Leaf [DOI]
- 44 Antitrypanosomal Tetranotriterpenoids from Toona ciliata roots [DOI]
- 45 In vitro preliminary study of antiprotozoal effect of four medicinal plants from Benin [DOI]
- 46 Current public health status of the trypanosomiases and leishmaniases.
- 47 Therapeutic activity of crude ethanolic extract of Artemisia herba alba against Trypanosoma evansi in rabbits [DOI]
- 48 Natural Products Active Against African Trypanosomes: A Step Towards New Drugs [DOI]
- 49 Some biochemical and haematological effects of black seed (Nigella sativa) oil on T. brucei-infected rats [DOI]
- 50 In vitro trypanocidal activity of some rare Tanzanian medicinal plants [DOI]
- 51 Comparative antitrypanosomal screening of methanolic extracts of khaya senegalensis and Moringa oleifera
- 52 African Journal of Traditional, Complementary and Alternative Medicines [DOI]
- 53 Veterinary Research Communications [DOI]
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