Skip to content
Research Article Open access CC BY 4.0

Activities of Datura stramonium Extracts against Clinical Pathogens

A. A. Odeleye, J. O. Obameso

South Asian Journal of Research in Microbiology · pp. 12–18 · Published 27 Jul 2022

10.9734/sajrm/2022/v13i230292

Abstract

Aim: The antimicrobial activities of the ethanolic extracts of D. Stramonium pulp, seed and leaf against some medically important pathogenic microorganisms were studied. Methodology: The antimicrobial activities of the ethanolic extracts of D. Stramonium pulp, seed and leaf were assessed on Bacillus subtilis, Streptococcus pneumoniae and Staphylococcus aureus (Gram-positive bacteria) and Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli (Gram-negative bacteria). Results: The highest percentage recovery at 50% ethanolic extract of leaf was 5.6±0.1 and lowest in Pulp with 3.9±0.1. The 50% ethanolic extracts showed significant activities against tested pathogens more than the 75% ethanolic extracts which, may be due to the effect of heat generated by water bath during extraction process. The plant extracts exerted highest zones of inhibition in pulp and seed extracts against P. aeruginosa with 21±1.0 and 17±2.0 respectively and least in K. pneumoniae with 10±0.5 from seed extract. The antimicrobial activities observed in this study were due to the presence of certain phytochemials that have bactericidal or inhibitory effects on  test organisms. These phytochemicals include  alkaloids, tannins, flavonoids, saponins, terpenoids, phenol and glycosides. Conclusion: D. stramonium extracts revealed very promising results with health-promoting potentials that could be applied in the treatment of ailments caused by these pathogens.

Datura stramonium pathogens ethanol extracts phytochemicals

References (26)

  1. 1 Phytochemical screening and Extraction: A Review
  2. 2 Ethnopharmacological approaches to wound healing—Exploring medicinal plants of India [DOI]
  3. 3 Concept of standardization, extraction and pre phytochemical screening strategies for herbal drug
  4. 4 Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production [DOI]
  5. 5 Pharmacological properties of Datura stramonium L. as a potential medicinal tree: An overview [DOI]
  6. 6 Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in Ethiopia [DOI]
  7. 7 A review on the pharmacological and toxicological aspects of Datura stramonium L. [DOI]
  8. 8 Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review [DOI]
  9. 9 Medical importance of Datura fastuosa (syn: Datura metel) and Datura stramonium - A review [DOI]
  10. 10 Antimicrobial activity of Datura innoxia and Datura stramonium [DOI]
  11. 11 Evaluation of in vivo antidiabetic, antidyslipidemic and in vitro antioxidant activities of hydromethanolic root extract of Datura stramonium L. (Solanaceae) [DOI]
  12. 12 Comparative studies on anti-inflammatory activity of Coriandrum sativum, Datura stramonium and Azadirachta indica.
  13. 13 Preclinical anticancer studies on the ethyl acetate leaf extracts of Datura stramonium and Datura inoxia [DOI]
  14. 14 Screening of phytochemicals, antioxidant and antibacterial activity of crude extract of Pteridium aquilinum Kuhn [DOI]
  15. 15 Datura metel: A Review on Chemical Constituents, Traditional Uses and Pharmacological Activities [DOI]
  16. 16 Datura stramonium Leaf Extract Exhibits Anti‐inflammatory Activity in CCL4‐Induced Hepatic Injury Model by Modulating Oxidative Stress Markers and iNOS/Nrf2 Expression [DOI]
  17. 17 Antibacterial activity of Datura stramonium against standard and clinical isolate pathogenic microorganisms [DOI]
  18. 18 Evaluation of Antibacterial Activity and Acute Toxicity of Methanol Extracts of Artemisia absinthium, Datura stramonium, and Solanum anguivi [DOI]
  19. 19 Toxicity studies of alkaloids of seeds of Datura stramonium and synthesis alkaloids in male rats [DOI]
  20. 20 Phytochemical, Preliminary Pharmacognostical and Antimicrobial Evaluation of Combined Crude Aqueous Extract
  21. 21 ANTIMICROBIAL SCREENING OF SEQUENTIAL EXTRACTS OF DATURA STRAMONIUM L.
  22. 22 In vitro vasodilatory effect of aqueous leaf extract of Thymus serrulatus on thoracic aorta of Guinea pigs [DOI]
  23. 23 Antimicrobial activity of Thymus schimperi Ronninger (Lamiaceae) against standard and clinical isolates of human pathogenic bacteria [DOI]
  24. 24 Antibacterial and Phytochemical Screening of Crude Extracts of Leaves and Seeds of Datura stramonium [DOI]
  25. 25 Internationale Pharmaceutica Sciencia [DOI]
  26. 26 Antimicrobial Investigation of Datura stramonium Leaf Extract against different Microorganisms. [DOI]

Cited by 0

No indexed citations yet.

Article metrics

Real usage data collected on this platform.

41

Page views

0

PDF downloads

17

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.